RELATIONSHIP BETWEEN BLOOD AND TISSUE MICRONUTRIENT

累积的流行病学和实验室研究结果表明 一些微量营养素可能会抑制或阻止致癌过程。 因为这些微量营养素可以在特定组织中发挥作用 部位，适当的微量营养素的目标组织浓度可能是 对预防癌症和/或癌前疾病至关重要。在……里面 为了确定微量营养素在癌症预防中的作用， 因此，研究各种组织中的微量营养素含量具有重要意义。 在人类中，尤其是那些有正常的、癌前病变和癌症的人。 在拟议的研究中，我们将确定不同的 微量营养素，包括维生素A、β-胡萝卜素、番茄红素和维生素 E，在正常人血浆、口腔粘膜细胞、皮肤和宫颈组织中 个人、高危人群和癌症患者。我们还将 比较正常人群和健康人群中微量营养素含量的差异， 同一癌症患者的癌前病变和癌组织以及 癌症患者的癌组织和正常组织之间的差异 配对的对照组。因为血液和口腔粘膜以外的其他组织 在人类体内很难获得细胞，因此，我们将研究 血浆和/或颊粘膜细胞的微量营养素含量是否可以 被用作评估其他动物微量营养素状况的指标 问题。这将通过调查两国关系来实现 这两种组织中的微量营养素含量与 人体皮肤、宫颈等靶组织的微量营养素含量 癌症患者和非癌症患者。用于分析的程序 对上述微量营养素的分析在我们的 实验室。广泛的质量控制/质量保证(QC/QA)计划 将遵循，以确保分析数据的准确性。 我们的实验室一直被评为最准确的实验室之一。 国家分析局参与者中的分析实验室 标准组织赞助的分析维生素A、β-胡萝卜素、 以及自1984年以来的维生素E。我们亚利桑那大学癌症研究小组 该中心是多学科的，并拥有开展 建议的研究。我们计划在4年内完成调查。

The accumulated epidemiologic and laboratory findings have suggested that some micronutrients may inhibit or prevent the process of carcinogenesis. Since these micronutrients may exert their actions at specific tissue sites, adequate target tissue concentration of the micronutrient may be critical for the prevention of cancer and/or precancerous conditions. In order to define the role of micronutrients in cancer prevention, it is, therefore, important to study the micronutrient content of various tissues in humans, especially those with normal, premalignant lesions, and cancers. In the proposed study, we will determine the content of various micronutrients, including vitamin A, beta-carotene, lycopene, and vitamin E, in plasma, buccal mucosal cells, skin, and cervical tissues of normal individuals, subjects at high risk, and cancer patients. We will also compare the difference in micronutrient content between normal, precancerous, and cancerous tissues of same cancer patient as well as between cancerous tissues from cancer patients and normal tissues from matched controls. Because tissues other than blood and buccal mucosal cells are difficult to obtain in humans, we will, therefore, investigate whether the micronutrient content of plasma and/or buccal mucosal cells can be used as an indicator for assessing the micronutrient status of other issues. This will be accomplished by investigating the relationship between the micronutrient content of these two tissues and the micronutrient content of the target tissues such as skin and cervix in cancer patients and non-cancer individuals. The analytical procedures for analysis of the above micronutrients are well established in our laboratory. An extensive quality control/quality assurance (QC/QA) program will be followed in order to assure the accuracy of the analytical data. Our laboratory has been consistently rated as one of the most accurate analytical laboratories among the participants in the National Bureau of Standards sponsored QC/QA program for analysis of vitamin A, beta-carotene, and vitamin E since 1984. Our group at the University of Arizona Cancer Center is multidisplinary and has the necessary expertise to conduct the proposed study. We plan to complete the investigations in 4 years.