CORE--ANALYTICAL CHEMISTRY

分析化学核心将在分析化学领域提供支持。 化学领域的所有项目在拟议的计划项目。 的 该核心的主要职责是分析提交的样品 项目调查人员准确、及时地进行调查， 调查人员可以在计划之前充满信心地评估数据， 下一阶段的调查。 待分析的化合物为 视黄醇、棕榈酸视黄酯、全反式视黄酸、13-顺式视黄酸、 维生素E、β-胡萝卜素、番茄红素、硒、安替比林和 人和动物血浆、皮肤、颊粘膜中的二氟甲基鸟氨酸 细胞肝脏和皮下脂肪 我们的检测程序 化合物已得到很好的确立，并已发表在同行评审 期刊 为了生成准确和一致的数据，核心将 继续遵循广泛的质量控制/质量保证计划 我们在保持现有的牢固关系的同时， 与国家标准局合作 核心还将提供 与调查人员就对 分析数据和/或与分析化学有关的任何事项。 在 此外，该核心将跟上该领域的最新发展 分析化学，以满足任何特殊的分析问题 未来可能面临的挑战 这个核心的实验室 配备了最新的分析仪器和主要的 研究者和核心小组的工作人员具有广泛的知识， 具备执行上述所有任务的经验。

The Analytical Chemistry Core will provide support in the analytical chemistry area for all projects in the proposed Program Project. The primary responsibility of this Core will be to analyze the sample submitted by the project investigators accurately and timely so that the investigators can evaluate the data with confidence before planning the next phase of their investigations. The compounds to be analyzed are retinol, retinyl-palmitate, all-trans-retinoic acid, 13-cis-retinoic acid, vitamin E, beta-carotene, lycopene, selenium, antipyrine and difluormethylornithine in human and animal plasma, skin, buccal mucosa cells, liver, and subcutaneous fat. Our assay procedures for these compounds are well established and have been published in peer-reviewed journals. In order to generate accurate and consistent data, the Core will continue to follow the extensive quality control/quality assurance program we have developed and carried out while maintaining the existing strong-tie with the National Bureau of Standards. The Core will also provide consultations to the investigators regarding the interpretation of analytical data and/or any matters related to analytical chemistry. In addition, this Core will keep abreast of current developments in the field of analytical chemistry in order to meet any special analytical problems the Core may face in the future. The laboratory of this Core is well equipped with up-to-date analytical instrument and the Principal Investigator and the staff members of the Core have extensive knowledge and experience in carrying out all the tasks mentioned above.