Warwick Integrative Synthetic Biology Centre

沃里克综合合成生物学中心

• 批准号: BB/M017982/1
• 负责人: John McCarthy
• 金额: $ 1582.66万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM017982%2F1
• 关键词: Warwick; Integrative; Synthetic; Biology; Centre

Synthetic biology is seen as a way to develop biology beyond naturally evolved biological systems to the benefit of mankind. It is a new type of engineering in which either existing parts of living cells are modified, or completely new parts are generated, in order to produce useful technologies and products. The function of the Warwick Integrative Synthetic Biology Centre (WISB) will be to establish a community of researchers from a range of relevant disciplines that will pursue the aims of synthetic biology following responsible procedures that are informed by considerations of ethical, legal and societal aspects. Our work will create products and technologies that will be valuable to multiple sectors, including biotechnology, health, food security and the environment. We will work in partnership with a wide range of companies that have interests in this area.At the core of WISB will be an underpinning commitment to developing synthetic biology technologies and knowhow that will both be useful to the wider community and will also enable progress in the applied projects that will be pursued in the Centre. This core activity is called Predictive Biosystems Engineering because the idea is to find ways of developing synthetic biological systems that behave in predictable ways. The benefit of this would be that predictable components can be assembled into more complex systems that also behave in predictable ways - this is a principle of fundamental importance in classical engineering. There are also three areas of more applied research:Engineering Biosynthetic Pathways is about building tailor-made and controllable pathways in living cells that direct the assembly of useful products, e.g. antimicrobials and anti-cancer drugs. Engineering principles will be applied with the objective of optimizing the productivity of these intracellular drug production lines.Engineering Microbial Communities is a research area in which we assemble different species of microbial organism that can be used in a range of biotechnological and biomedical applications. For example, synthetic communities of this type will be able to degrade noxious and toxic compounds from the environment, or could be utilized to treat diseases of the skin or gut.Engineering Microbial Effector Systems research will take advantage of the fascinating interplay between plants and microbial species with which they interact in Nature, for example in the soil. Such microorganisms use a range of molecules, called effectors, to modify the genetic and metabolic systems of plant cells. By re-engineering these interactions, we will be able to enhance the properties of plants, thus contributing to food security.In parallel to the above activities, WISB will perform research on the ethical, legal and societal aspects of synthetic biology and follow principles of responsible research and innovation. We will engage in a wide range of outreach activities in order to communicate our research philosophy and findings to the wider community. A special feature of this outreach will involve work and presentations on the relationships between technology, design and art.Finally, WISB will be fully committed to education and training in synthetic biology, thus ensuring that we contribute strongly to the training of future generations of synthetic biology researchers.

合成生物学被认为是一种超越自然进化的生物系统来发展生物学以造福人类的方法。它是一种新型的工程，其中活细胞的现有部分被修改，或者产生全新的部分，以产生有用的技术和产品。沃里克综合合成生物学中心（WISB）的职能将是建立一个来自一系列相关学科的研究人员社区，这些学科将遵循道德，法律的和社会方面的考虑所告知的负责任的程序来追求合成生物学的目标。我们的工作将创造对多个部门有价值的产品和技术，包括生物技术、卫生、粮食安全和环境。我们将与在这一领域感兴趣的广泛公司合作。WISB的核心是致力于开发合成生物学技术和专有技术，这些技术和专有技术不仅对更广泛的社区有用，而且还将促进中心开展的应用项目的进展。这个核心活动被称为预测生物系统工程，因为这个想法是找到开发合成生物系统的方法，这些系统以可预测的方式运行。这样做的好处是，可预测的组件可以组装成更复杂的系统，这些系统也以可预测的方式运行-这是经典工程中的一个基本重要原则。还有三个更应用的研究领域：工程生物合成途径是关于在活细胞中构建量身定制和可控的途径，指导有用产品的组装，例如抗菌剂和抗癌药物。工程原理将应用于优化这些细胞内药物生产线的生产力。工程微生物群落是一个研究领域，我们组装不同种类的微生物，可用于一系列生物技术和生物医学应用。例如，这种类型的合成群落将能够降解环境中的有毒有害化合物，或者可以用于治疗皮肤或肠道疾病。工程微生物效应系统研究将利用植物和微生物物种之间的迷人相互作用，它们在自然界中相互作用，例如在土壤中。这些微生物使用一系列称为效应子的分子来改变植物细胞的遗传和代谢系统。通过重新设计这些相互作用，我们将能够增强植物的特性，从而为粮食安全做出贡献。在上述活动的同时，WISB将进行合成生物学的伦理，法律的和社会方面的研究，并遵循负责任的研究和创新原则。我们将开展广泛的外展活动，以便向更广泛的社区传达我们的研究理念和研究成果。这次推广活动的一个特点将涉及技术，设计和艺术之间的关系的工作和演示。最后，WISB将完全致力于合成生物学的教育和培训，从而确保我们为未来几代合成生物学研究人员的培训做出强有力的贡献。

项目成果

Commentary: Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome.

• DOI: 10.3389/fcimb.2018.00104
• 发表时间: 2018
• 期刊: Frontiers in cellular and infection microbiology
• 影响因子: 5.7
• 作者: Anonye BO

Triggering the expression of a silent gene cluster from genetically intractable bacteria results in scleric acid discovery

触发遗传难治性细菌沉默基因簇的表达导致巩膜酸的发现

• DOI: 10.1101/265645
• 发表时间: 2018
• 作者: Alberti F

Scarless Recombineering of Phage in Lysogenic State.

• DOI: 10.1007/978-1-0716-2233-9_1
• 发表时间: 2022-01-01
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Ababi, Maria;Tridgett, Matthew;Jaramillo, Alfonso
• 通讯作者: Jaramillo, Alfonso

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

• DOI: 10.1126/scisignal.aaw2939
• 发表时间: 2019-08-13
• 期刊: SCIENCE SIGNALING
• 影响因子: 7.3
• 作者: Adib, Rozita;Montgomery, Jessica M.;Fry, Andrew M.
• 通讯作者: Fry, Andrew M.

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).

• DOI: 10.1074/jbc.ra118.002597
• 发表时间: 2018-06-22
• 期刊: The Journal of biological chemistry
• 作者: Ahangar MS;Furze CM;Guy CS;Cooper C;Maskew KS;Graham B;Cameron AD;Fullam E
• 通讯作者: Fullam E