SynthSys-Mammalian: Edinburgh Mammalian Synthetic Biology Research Centre

爱丁堡哺乳动物合成生物学中心（SynthSys-Mammalian）的愿景是率先开发实施工程原理并实现哺乳动物系统中合成生物学的全部潜力所需的基础工具和技术。我们有一个雄心勃勃的计划，在细胞工程工具生成、全细胞建模、计算机辅助设计和DNA构建以及高通量表型分析方面建立内部专业知识，以使哺乳动物系统中的合成生物学能够用于多种应用。通过这种方式，我们不仅将推进对哺乳动物生物学的基本理解，而且还将产生用于制药和药物测试行业等领域的近期商业开发的工具和技术，生物传感细胞系传感用于诊断的疾病生物标志物，新型治疗剂，基于蛋白质的药物的生产，例如抗体，以及再生医学应用程序的干细胞开发和分化。与此同时，我们将发展和实施对这项意义深远的技术的社会和经济影响的新理解，以确保其对社会的好处。

The vision for Edinburgh's Centre for Mammalian Synthetic Biology (SynthSys-Mammalian) is to pioneer the development of the underpinning tools and technologies needed to implement engineering principles and realise the full potential of synthetic biology in mammalian systems. We have an ambitious plan to build in-house expertise in cell engineering tool generation, whole-cell modelling, computer-assisted design and construction of DNA and high-throughput phenotyping to enable synthetic biology in mammalian systems for multiple applications. In this way we will not only advance basic understanding of mammalian biology but also generate tools and technologies for near-term commercial exploitation in areas such as the pharmaceutical and drug testing industries, biosensing cell lines sensing disease biomarkers for diagnositics, novel therapeutics, production of protein based drugs e.g. antibodies and also programming stem cell development and differentiation for regenerative medicine applications. In parallel we will develop and implement new understanding of the social and economic impact of this far-reaching technology to ensure its benefits to society.