SynthSys-Mammalian: Edinburgh Mammalian Synthetic Biology Research Centre

SynthSys-Mammalian：爱丁堡哺乳动物合成生物学研究中心

• 批准号: BB/M018040/1
• 负责人: Susan Rosser
• 金额: $ 1600.1万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM018040%2F1
• 关键词: SynthSys; Mammalian; Edinburgh; Synthetic; Biology

The vision for Edinburgh's Centre for Mammalian Synthetic Biology (SynthSys-Mammalian) is to pioneer the development of the underpinning tools and technologies needed to implement engineering principles and realise the full potential of synthetic biology in mammalian systems. We have an ambitious plan to build in-house expertise in cell engineering tool generation, whole-cell modelling, computer-assisted design and construction of DNA and high-throughput phenotyping to enable synthetic biology in mammalian systems for multiple applications. In this way we will not only advance basic understanding of mammalian biology but also generate tools and technologies for near-term commercial exploitation in areas such as the pharmaceutical and drug testing industries, biosensing cell lines sensing disease biomarkers for diagnositics, novel therapeutics, production of protein based drugs e.g. antibodies and also programming stem cell development and differentiation for regenerative medicine applications. In parallel we will develop and implement new understanding of the social and economic impact of this far-reaching technology to ensure its benefits to society.

爱丁堡哺乳动物合成生物学中心(SynthSys-哺乳动物)的愿景是率先开发实施工程原理所需的支撑工具和技术，并在哺乳动物系统中实现合成生物学的全部潜力。我们有一个雄心勃勃的计划，要在细胞工程工具生成、全细胞建模、计算机辅助设计和DNA构建以及高通量表型鉴定方面建立内部专业知识，以使哺乳动物系统中的合成生物学能够用于多种应用。通过这种方式，我们不仅将促进对哺乳动物生物学的基本了解，而且还将产生工具和技术，用于近期在制药和药物测试行业、生物传感细胞系检测疾病生物标记物用于诊断、新疗法、生产基于蛋白质的药物(例如抗体)以及为再生医学应用编程干细胞开发和分化等领域的商业开发。同时，我们将发展和实施对这项影响深远的技术的社会和经济影响的新理解，以确保其对社会的好处。

项目成果

Genetic Constructor: An Online DNA Design Platform.

Genetic Constructor：在线 DNA 设计平台。

• DOI: 10.1021/acssynbio.7b00236
• 发表时间: 2017
• 期刊: ACS synthetic biology
• 影响因子: 4.7
• 作者: Bates M

Understanding the emergence and evolution of new business models in the UK regenerative medicine sector

• DOI: 10.1080/09537325.2019.1685087
• 发表时间: 2019-11
• 期刊: Technology Analysis & Strategic Management
• 影响因子: 3.4
• 作者: Geoffrey Banda;James Mittra;J. Tait;Andrew Watkins;O. Omidvar

Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.

• DOI: 10.1038/s41598-018-32929-7
• 发表时间: 2018-10-09
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Baaske J;Gonschorek P;Engesser R;Dominguez-Monedero A;Raute K;Fischbach P;Müller K;Cachat E;Schamel WWA;Minguet S;Davies JA;Timmer J;Weber W;Zurbriggen MD
• 通讯作者: Zurbriggen MD

Taking Roles in Interdisciplinary Collaborations: Reflections on working in Post-ELSI Spaces in the UK Synthetic Biology Community

在跨学科合作中发挥作用：对英国合成生物学界后 ELSI 空间工作的反思

• 发表时间: 2015
• 期刊: Science and Technology Studies
• 影响因子: 1.2
• 作者: Balmer, A

Five rules of thumb for post-ELSI interdisciplinary collaborations

• DOI: 10.1080/23299460.2016.1177867
• 发表时间: 2016-01-01
• 期刊: JOURNAL OF RESPONSIBLE INNOVATION
• 影响因子: 3.9
• 作者: Balmer, Andrew S.;Calvert, Jane;Martin, Paul
• 通讯作者: Martin, Paul