Industrial Saponins

工业皂苷

• 批准号: BB/M028860/1
• 负责人: Susan Rosser
• 金额: $ 44.82万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FM028860%2F1
• 关键词: Industrial; Saponins

The aim of this project is to bring saponin production into the domain of industrial biotechnology to make this diverse groupof biosurfactants available for commercial exploitation at the required scale, structure specificity & cost, in the first instancefor home & personal care (HPC) use. We have already demonstrated that saponins can synergise with conventionalsurfactants to reduce the total surfactant level required for cleaning performance in laundry detergents, and that suchmixtures are particularly effective at low temperatures. Saponins are plant-derived triterpenoidal or steroidal surfactants.Saponins currently have limited commercial availability, being sourced from natural plant materials. This supply is deficientin scale, is of limited structure specificity and is too expensive for Unilever's intended use in laundry detergents. Unilever'sconcentrated detergents business alone would require 100 tonnes pa of saponin at 0.1% level and 20% product rangepenetration. Leading saponin supplier Desert King produces only 20 tonnes active saponin pa from natural extracts.Furthermore, we have demonstrated that certain saponin structures are significantly more effective than others. The currentsources of saponins are natural extracts and comprise a heterogeneous mixture of saponin structures. Our IB innovationwill enable considerable enrichment for the most effective saponin structures. Current commercial saponins are tooexpensive at $35/kg for crude extracts for use in anything other than premium products. We expect IB to be a more costeffective route to saponin supply.

该项目的目的是将皂素生产纳入工业生物技术领域，使这类多样化的生物表面活性剂能够在第一时间以所需的规模、结构特性和成本用于商业开发，并用于家庭和个人护理(HPC)。我们已经证明，皂苷可以与传统表面活性剂协同作用，降低洗涤剂中清洁性能所需的总表面活性剂水平，而且这种混合物在低温下尤其有效。皂苷是植物来源的三萜或甾体表面活性剂。目前皂苷的商业用途有限，主要来源于天然植物原料。这种供应缺乏规模，结构特异性有限，对于联合利华在洗衣粉中的预期用途来说过于昂贵。仅联合利华的浓缩洗涤剂业务就需要100吨0.1%水平的皂素和20%的产品范围。领先的皂素供应商Desert King仅从天然提取物中生产20吨活性皂素PA。此外，我们已经证明，某些皂素结构明显比其他结构更有效。目前皂苷的来源是天然提取物，由皂素结构的异质混合物组成。我们的IB创新将使最有效的皂素结构得到相当大的丰富。目前商业皂苷的粗提物价格太高，每公斤35美元，用于除优质产品以外的任何产品。我们预计IB将是一条更具成本效益的皂素供应途径。

项目成果

Plant metabolic clusters - from genetics to genomics.

• DOI: 10.1111/nph.13981
• 发表时间: 2016-08
• 期刊: The New phytologist
• 作者: Nützmann HW;Huang A;Osbourn A
• 通讯作者: Osbourn A

Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways.

• DOI: 10.1039/c6np00035e
• 发表时间: 2016-08-27
• 期刊: Natural product reports
• 影响因子: 11.9
• 作者: Medema MH;Osbourn A
• 通讯作者: Osbourn A

plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters.

Plantismash：植物生物合成基因簇的自动鉴定，注释和表达分析。

• DOI: 10.1093/nar/gkx305
• 发表时间: 2017-07-03
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Kautsar SA;Suarez Duran HG;Blin K;Osbourn A;Medema MH
• 通讯作者: Medema MH

Minimum Information about a Biosynthetic Gene cluster.

• DOI: 10.1038/nchembio.1890
• 发表时间: 2015-09
• 期刊: Nature chemical biology
• 影响因子: 14.8
• 作者: Medema MH;Kottmann R;Yilmaz P;Cummings M;Biggins JB;Blin K;de Bruijn I;Chooi YH;Claesen J;Coates RC;Cruz-Morales P;Duddela S;Düsterhus S;Edwards DJ;Fewer DP;Garg N;Geiger C;Gomez-Escribano JP;Greule A;Hadjithomas M;Haines AS;Helfrich EJ;Hillwig ML;Ishida K;Jones AC;Jones CS;Jungmann K;Kegler C;Kim HU;Kötter P;Krug D;Masschelein J;Melnik AV;Mantovani SM;Monroe EA;Moore M;Moss N;Nützmann HW;Pan G;Pati A;Petras D;Reen FJ;Rosconi F;Rui Z;Tian Z;Tobias NJ;Tsunematsu Y;Wiemann P;Wyckoff E;Yan X;Yim G;Yu F;Xie Y;Aigle B;Apel AK;Balibar CJ;Balskus EP;Barona-Gómez F;Bechthold A;Bode HB;Borriss R;Brady SF;Brakhage AA;Caffrey P;Cheng YQ;Clardy J;Cox RJ;De Mot R;Donadio S;Donia MS;van der Donk WA;Dorrestein PC;Doyle S;Driessen AJ;Ehling-Schulz M;Entian KD;Fischbach MA;Gerwick L;Gerwick WH;Gross H;Gust B;Hertweck C;Höfte M;Jensen SE;Ju J;Katz L;Kaysser L;Klassen JL;Keller NP;Kormanec J;Kuipers OP;Kuzuyama T;Kyrpides NC;Kwon HJ;Lautru S;Lavigne R;Lee CY;Linquan B;Liu X;Liu W;Luzhetskyy A;Mahmud T;Mast Y;Méndez C;Metsä-Ketelä M;Micklefield J;Mitchell DA;Moore BS;Moreira LM;Müller R;Neilan BA;Nett M;Nielsen J;O'Gara F;Oikawa H;Osbourn A;Osburne MS;Ostash B;Payne SM;Pernodet JL;Petricek M;Piel J;Ploux O;Raaijmakers JM;Salas JA;Schmitt EK;Scott B;Seipke RF;Shen B;Sherman DH;Sivonen K;Smanski MJ;Sosio M;Stegmann E;Süssmuth RD;Tahlan K;Thomas CM;Tang Y;Truman AW;Viaud M;Walton JD;Walsh CT;Weber T;van Wezel GP;Wilkinson B;Willey JM;Wohlleben W;Wright GD;Ziemert N;Zhang C;Zotchev SB;Breitling R;Takano E;Glöckner FO
• 通讯作者: Glöckner FO

Harnessing plant metabolic diversity.

• DOI: 10.1016/j.cbpa.2017.04.015
• 发表时间: 2017-10
• 期刊: Current opinion in chemical biology
• 影响因子: 7.8
• 作者: Owen C;Patron NJ;Huang A;Osbourn A
• 通讯作者: Osbourn A