CEREBRAL BLOOD FLOW & METBOLISM AFTER MARIJUANA SMOKING

脑血流量

• 批准号: 3210872
• 负责人: ROY MATHEW
• 金额: $ 32.13万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3210872
• 关键词: behavior; blood flow measurement; brain metabolism; emotions; human subject; marijuana abuse; noninvasive diagnosis; positron emission tomography; psychopharmacology

The behavioral manifestations and complications of marijuana smoking are probably associated with changes in brain function. With the advent of noninvasive measurement techniques, it is now possible to quantify cerebral blood flow (CBF) and cerebral metabolism (CMR), two indices of brain function in human subjects noninvasively. No information is available on the effects of marijuana on CBF and CMR. The study proposed here is divided into two sections. In Section I, CBF, behavior and mood will be measured before and thrice after smoking high-potency marijuana (2.5% THC), low potency marijuana (1% THC) and a placebo in 48 experienced marijuana smokers (ES and 48 inexperienced marijuana smokers (IS). The high-potency and low- potency marijuana and a placebo will be administered to all subjects and each individual would have had a total of 12 CBF measurements. CBF measurements in this section will be performed with the 133Xenon inhalation technique. The second section involves the measurement of CBF and CMR for oxygen together with behavior and mood before and twice after smoking high-potency (2.5% THC) marijuana (16 ES and 16 IS) or a placebo (8 ES and 8 IS). The measurements will be carried out with Positron Emissin Tomography (PET).

大麻的行为表现和并发症 吸烟可能与大脑功能的变化有关。 随着非侵入性测量技术的出现，现在是 可以量化脑血流量(CBF)和脑 人体脑功能的两个指标--新陈代谢 受试者是非侵入性的。目前还没有关于影响的信息。 在CBF和CMR上吸食大麻。这里提出的研究是 分为两个部分。在第一节，CBF，行为和情绪 会在吸烟前后测量三次高效力 大麻(2.5%THC)、低效大麻(1%THC)和 48名有经验的大麻吸烟者(ES和48人)服用安慰剂 没有经验的大麻吸烟者(IS)。高效力和低效力- 效力大麻和安慰剂将分发给所有人 受试者和每个人总共有12个CBF 测量。本节中的CBF测量值将为 采用133Xenon吸入技术。第二 部分涉及对氧的CBF和CMR的测量 吸烟前和吸烟后两次的行为和情绪 高效力(2.5%THC)大麻(16ES和16IS)或安慰剂 (8个ES和8个IS)。测量将在以下情况下进行 正电子发射断层扫描(PET)。