ANXIETY AND REGIONAL CEREBRAL BLOOD FLOW

焦虑与区域脑血流

• 批准号: 3381385
• 负责人: ROY MATHEW
• 金额: $ 20.7万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3381385
• 关键词: anxiety; blood flow measurement; cerebral ischemia /hypoxia; cerebrovascular disorder diagnosis; disease /disorder proneness /risk; epinephrine; human subject; mitral valve insufficiency; neurochemistry; stress; stroke

The aim of the study is to evaluate the association between regional cerebral blood flow (rCBF) and anxiety. Regional cerebral blood flow will be measured under resting conditions and during acute anxiety in patients with anxiety disorders and matched normal controls. 133Xenon inhalation technique will be utilized for measurement of the brain capillary perfusion. Degrees of anxiety during the cerebral blood flow measurement will be quantified via rating scales and peripheral physiological indices. Several anxiety related variables such as hematocrit, fibrinogen, hemoglobin and carbon dioxide which have been implicated in the control of cerebral blood flow will be monitored. Anxiety will be induced in both patients and controls via an intravenous infusion of .2 microgram/Kg/mt of epinephrine or normal saline given under double-blind conditions. This project might identify the brain regions related to anxiety. This information will be of considerable value to similar research projects on other psychiatric illnesses since anxiety is a component of most psychiatric conditions. It will also examine the possible use of CBF as an objective index of anxiety. The result of the study may facilitate neurochemistry research on psychiatric disorders. It would also explain the central mechanisms of cerebral ischemia, commonly associated with acute anxiety. Lastly, it might provide new insights into the association between anxiety, mitral valve prolapse and stroke.

本研究的目的是评估 局部脑血流量（rCBF）和焦虑。 区域 将在静息条件下测量脑血流量， 在焦虑症患者的急性焦虑期间， 匹配正常对照。 133氙吸入技术将是 用于测量脑毛细血管灌注。 脑血流量测定中的焦虑程度 将通过评定量表和外周生理 指数。 几个焦虑相关的变量，如红细胞压积， 纤维蛋白原、血红蛋白和二氧化碳， 将监测与脑血流控制有关的药物。 焦虑将在患者和对照组中诱导， 静脉输注0.2 μ g/Kg/mt肾上腺素或 在双盲条件下给予生理盐水。 这个项目可能会识别与焦虑有关的大脑区域。 这一信息对类似的研究将具有相当大的价值 其他精神疾病的项目，因为焦虑是一个 是大多数精神疾病的组成部分。 委员会还将审查 CBF作为焦虑的客观指标的可能性。 的 研究结果可能有助于神经化学研究， 精神疾病 这也可以解释中央 脑缺血的机制，通常与 急性焦虑 最后，它可能会提供新的见解 焦虑、二尖瓣脱垂和中风之间的关系。