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ANXIETY AND REGIONAL CEREBRAL BLOOD FLOW

焦虑与区域脑血流

基本信息

批准号：
3376741
负责人：
ROY MATHEW
金额：
$ 6.96万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
起止时间：
1983-12-01 至 1986-01-31
项目状态：
已结题

项目摘要

The aim of the study is to evaluate the association between regional cerebral blood flow (rCBF) and anxiety. Regional cerebral blood flow will be measured under resting conditions and during acute anxiety in patients with anxiety disorders and matched normal controls. 133Xenon inhalation technique will be utilized for measurement of the brain capillary perfusion. Degrees of anxiety during the cerebral blood flow measurement will be quantified via rating scales and peripheral physiological indices. Several anxiety related variables such as hematocrit, fibrinogen, hemoglobin and carbon dioxide which have been implicated in the control of cerebral blood flow will be monitored. Anxiety will be induced in both patients and controls via an intravenous infusion of .2 microgram/Kg/mt of epinephrine or normal saline given under double-blind conditions. This project might identify the brain regions related to anxiety. This information will be of considerable value to similar research projects on other psychiatric illnesses since anxiety is a component of most psychiatric conditions. It will also examine the possible use of CBF as an objective index of anxiety. The results of the study may facilitate neurochemistry research on psychiatric disorders. It would also explain the central mechanisms of cerebral ischemia, commonly associated with acute anxiety. Lastly, it might provide new insights into the association between anxiety, mitral valve prolapse and stroke.

这项研究的目的是评估区域之间的联系脑血流量(RCBF)和焦虑。局部脑血流将患者在静息状态下和急性焦虑状态下的测量患有焦虑症的患者和匹配的正常对照组。133Xe吸入剂这项技术将用于测量大脑毛细血管灌流。脑血流测量中的焦虑程度将通过评级量表和外周生理指数进行量化。一些与焦虑相关的变量，如红细胞压积、纤维蛋白原、血红蛋白和二氧化碳已被牵连到控制将监测脑血流量。在这两种情况下都会诱发焦虑患者和对照组静脉输注0.2微克/公斤/毫升在双盲条件下给予肾上腺素或生理盐水。这个项目可能会识别与焦虑相关的大脑区域。这这些信息将对类似的研究项目具有相当大的价值其他精神疾病，因为焦虑是大多数精神疾病。它还将研究CBF作为一种焦虑的客观指标。研究的结果可能有助于精神障碍的神经化学研究。这也解释了脑缺血的中枢机制，通常与急性焦虑。最后，它可能会提供对该协会的新见解在焦虑、二尖瓣脱垂和中风之间。