CEREBRAL BLOOD FLOW & METBOLISM AFTER MARIJUANA SMOKING

脑血流量

• 批准号: 3210869
• 负责人: ROY MATHEW
• 金额: $ 28.16万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3210869
• 关键词: behavior; blood flow measurement; brain metabolism; emotions; human subject; marijuana abuse; noninvasive diagnosis; positron emission tomography; psychopharmacology

The behavioral manifestations and complications of marijuana smoking are probably associated with changes in brain function. With the advent of noninvasive measurement techniques, it is now possible to quantify cerebral blood flow (CBF) and cerebral metabolism (CMR), two indices of brain function in human subjects noninvasively. No information is available on the effects of marijuana on CBF and CMR. The study proposed here is divided into two sections. In Section I, CBF, behavior and mood will be measured before and thrice after smoking high-potency marijuana (2.5% THC), low potency marijuana (1% THC) and a placebo in 48 experienced marijuana smokers (ES and 48 inexperienced marijuana smokers (IS). The high-potency and low- potency marijuana and a placebo will be administered to all subjects and each individual would have had a total of 12 CBF measurements. CBF measurements in this section will be performed with the 133Xenon inhalation technique. The second section involves the measurement of CBF and CMR for oxygen together with behavior and mood before and twice after smoking high-potency (2.5% THC) marijuana (16 ES and 16 IS) or a placebo (8 ES and 8 IS). The measurements will be carried out with Positron Emissin Tomography (PET).

大麻的行为表现和并发症 吸烟可能与大脑功能的变化有关。 随着非侵入性测量技术的出现， 可以量化脑血流量（CBF）和脑 脑代谢（CMR），人类脑功能的两个指标 非侵入性的实验。 没有关于影响的信息 CBF和CMR的大麻含量 这里提出的研究是 分为两个部分。 在第一部分，CBF，行为和情绪， 将在吸烟前和吸烟后三次测量高效能 大麻（2.5% THC），低效能大麻（1% THC）和 48名有经验的大麻吸烟者（ES和48名 无经验的大麻吸食者（IS）。 高效能和低- 强效大麻和安慰剂将被给予所有 受试者和每个人总共有12个CBF 测量. 本节中的CBF测量将 使用133氙吸入技术进行。 第二 本节涉及氧的CBF和CMR测量 以及吸烟前后两次的行为和情绪 高效（2.5% THC）大麻（16 ES和16 IS）或安慰剂 （8个ES和8个IS）。 测量将在以下条件下进行： 正电子发射断层扫描（PET）。