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Transcriptional regulation of plant growth in nuclear micro domains.

核微域植物生长的转录调控。

基本信息

批准号：
BB/M023079/1
负责人：
EIRINI KAISERLI
金额：
$ 59.56万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FM023079%2F1
关键词：
Transcriptional regulation plant growth nuclear

项目摘要

To achieve "sustainable production of sufficient food to supply the world's growing population" scientists need to develop a strategy to promote plant growth by optimising light capture and energy production. One of the most dramatic developmental transitions in a plant's life cycle occurs during photomorphogenesis, when a seedling emerges from the soil and develops leaves, chloroplasts, an embryonic stem, roots and starts producing photoprotective compounds. The majority of these processes are regulated at the transcriptional level. To fully understand the principles of transcriptional regulation of gene expression I propose to employ an innovative approach to investigating where, when and how environmental and endogenous stimuli integrate and signalling pathways cross-talk within the nucleus to coordinate the expression of genes that are essential for optimising plant growth. More specifically, we will investigate the function of a novel key nuclear signal integrator of environmental and endogenous stimuli in regulating gene expression. TZP is a nuclear component that plays a major role in integrating light, hormone and clock networks to accelerate plant growth. Plants expressing increased levels of TZP develop longer hypocotyls, petioles and stems that allow them to outperform their neighbours for light capture and energy production. Most crop plant species including soybean, rice, barley and brassicacea contain TZP orthologs in their genome, which is an indication of its functional significance across species. TZP could provide a new target for accelerating growth rates, seedling establishment and survival in economically valuable crop species. Furthermore, characterisation of highly conserved processes, such as transcriptional activation and signal integration will also contribute to the general knowledge of the regulation of gene expression in eukaryotes and facilitate the development of predictive disease screening.The scientific scope of this research plan is encompassed within the strategic priorities of the BBSRC. Firstly, accelerating plant growth will have major applications in crop science. Secondly, the mechanism of transcriptional regulation of gene expression and nuclear compartmentalisation are fundamental and highly conserved processes among eukaryotic organisms. Findings stemming from this research proposal will have direct relevance to research on crop science as well as healthy ageing.

为了实现“可持续地生产足够的粮食来供应世界不断增长的人口”，科学家需要制定一项战略，通过优化光捕获和能源生产来促进植物生长。植物生命周期中最引人注目的发育转变之一发生在光形态建成期间，当幼苗从土壤中出现并发育叶子，叶绿体，胚胎茎，根并开始产生光保护化合物时。这些过程中的大多数是在转录水平上调节的。为了充分了解基因表达的转录调控的原则，我建议采用一种创新的方法来研究在哪里，何时以及如何环境和内源性刺激整合和信号传导途径的细胞核内的串扰，以协调基因的表达，是必不可少的优化植物生长。更具体地说，我们将研究一种新的关键核信号整合环境和内源性刺激在调节基因表达的功能。TZP是一种核组分，在整合光、激素和时钟网络以加速植物生长方面起着重要作用。表达增加水平的TZP的植物发育出更长的下胚轴、叶柄和茎，这使得它们在光捕获和能量产生方面优于它们的邻居。包括大豆、水稻、大麦和芸苔科在内的大多数作物物种在其基因组中含有TZP直系同源物，这表明其在物种间的功能意义。TZP可以为加快经济作物的生长速率、幼苗建立和存活提供新的靶标。此外，高度保守的过程，如转录激活和信号整合的表征也将有助于真核生物基因表达调控的一般知识，并促进预测疾病screen.The本研究计划的科学范围内的战略重点BBSRC的发展。首先，加速植物生长将在作物科学中有重要应用。其次，基因表达的转录调控机制和核区室化是真核生物中基本的和高度保守的过程。这项研究提案的结果将与作物科学和健康老龄化的研究直接相关。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Ultraviolet Rays Light Up Transcriptional Networks Regulating Plant Growth.

DOI：
10.1016/j.devcel.2018.02.005
发表时间：
2018-02
期刊：
Developmental cell
影响因子：
11.8
作者：
E. Kaiserli
通讯作者：
E. Kaiserli

Photobody Detection Using Immunofluorescence and Super-Resolution Imaging in Arabidopsis.

在拟南芥中使用免疫荧光和超分辨率成像进行光体检测。

DOI：
10.1007/978-1-0716-1370-2_2
发表时间：
2021
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
0
作者：
Perrella G
通讯作者：
Perrella G

Light and temperature shape nuclear architecture and gene expression.

DOI：
10.1016/j.pbi.2018.05.018
发表时间：
2018-10
期刊：
Current opinion in plant biology
影响因子：
9.5
作者：
Kaiserli E;Perrella G;Davidson ML
通讯作者：
Davidson ML

CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.

DOI：
10.1111/tpj.14955
发表时间：
2020-11
期刊：
The Plant journal : for cell and molecular biology
影响因子：
0
作者：
Inoue SI;Kaiserli E;Zhao X;Waksman T;Takemiya A;Okumura M;Takahashi H;Seki M;Shinozaki K;Endo Y;Sawasaki T;Kinoshita T;Zhang X;Christie JM;Shimazaki KI
通讯作者：
Shimazaki KI

Light, chromatin, action: nuclear events regulating light signaling in Arabidopsis.

DOI：
10.1111/nph.18424
发表时间：
2022-10
期刊：
NEW PHYTOLOGIST
影响因子：
9.4
作者：
Patitaki, Eirini;Schivre, Geoffrey;Zioutopoulou, Anna;Perrella, Giorgio;Bourbousse, Clara;Barneche, Fredy;Kaiserli, Eirini
通讯作者：
Kaiserli, Eirini