Reaching new heights in high-resolution electron microscopy

达到高分辨率电子显微镜的新高度

• 批准号: LE150100149
• 负责人: Prof Benjamin Hankamer
• 金额: $ 39.34万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE150100149
• 关键词: Reaching; new; heights; resolution; electron

High-resolution electron microscopy (EM): Direct electron detection cameras are a recent technological breakthrough delivering one of the greatest single advancements to the field of molecular cryo-EM. The aim of this project is to enable a 'first of a kind' cryo-EM platform in Australia enabling high-throughput atomic resolution protein structure determination. This will be achieved by integrating a state-of-the-art Gatan K2 Summit Direct Electron Detection camera system into the established cryo-EM facility managed by the University of Queensland node of the Australian Microscopy and Microanalysis Facility. This will offer unique and significantly improved capabilities for atomic resolution protein structure analysis, and will support a broad range of projects across the biological sciences.

高分辨率电子显微镜（EM）：直接电子检测相机是最近的技术突破，为分子冷冻EM领域带来了最大的单一进步之一。该项目的目的是在澳大利亚建立一个“首个”冷冻EM平台，实现高通量原子分辨率蛋白质结构测定。这将通过将最先进的Gatan K2 Summit直接电子检测相机系统集成到由澳大利亚显微镜和微量分析设施的昆士兰州大学节点管理的已建立的低温EM设施中来实现。这将为原子分辨率蛋白质结构分析提供独特和显著改进的能力，并将支持整个生物科学的广泛项目。