权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

BEHAVIORAL CORRELATES OF HTLV-III AND IMMUNE DEFICIENCY

HTLV-III 和免疫缺陷的行为相关性

基本信息

批准号：
3209777
负责人：
Howard B Kaplan
金额：
$ 14.9万
依托单位：
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-06-01 至 1990-08-31
项目状态：
已结题

项目摘要

The proposal will build upon an ongoing longitudinal study of 6,000 subjects who were tested up to three times during their junior high school years (1971-73) and again as young adults (between 1981 and 1986) in order to test theoretical models of the adoption and changes in level of involvement in more or less deviant adaptations to life stresses. By obtaining data from a second adult interview and from blood samples from a portion of these subjects (N=1800) we will test theoretically informed multivariate models of the mutually influential more and less proximate precursors of 1) infection with HTLV-III (indicated by ELISA, immunofluoresence, culture), 2) immune deficiency data (reflected in differentiation marker studies and functional tests), 3) changes in behaviors that are recognized as implicated in infectiion with AIDS virus, and 4) responses to threats to self-conceptions posed by the request to provide blood samples, the expectation of receiving information regarding the test outcome, knowledge of the test results, and symptoms associated with HTLV-III infection, using a range of multivariate analytic strategies. We aim to conduct four sets of analyses guided by previously formulated general theoretical paradigms and comprehensive reviews of the literature. Explanatory factors in the first set of models include parenteral drug use, homosexual patterns such as anal receptive intercourse, sexual promiscuity, as well as the psychosocial factors that increase the opportunity to learn and to become motivated to engage in these patterns. In the second set of models explanatory factors include various patterns of substance abuse, psychosocial stress, nutrition, other indicators of health status, and the biopsychosocial precursors of these factors that facilitate the learning, motivation to engage in, or experience of these patterns. These factors are not of the direct or indirect effects of HTLV-III infection or its precursors upon immunodepressive states. In the third set of models, explanatory factors further include beliefs about the consequences and the subjective evaluative significance of the behaviors that are in fact and/or believed to be implicated in the onset and course of AIDS and the risk status of the person for contracting HTLV-III infection. For the fourth set of models, explanatory factors include characteristic adaptive/coping/defensive patterns, personal and interpersonal resources (both instrumental and socioemotional), the evaluative significance of threatened social roles, and awareness of the potentially threatening AIDS-related stimuli, and the precursors of these factors.

该提案将建立在正在进行的关于 6000名受试者在他们的研究过程中接受了最多三次测试初中时期(1971-73)，再一次成为年轻人 (在1981至1986年间)，以检验对更多或更多客户的采纳和参与程度的变化对生活压力的适应不那么离谱。通过获取数据从第二次成人面谈和一名这些科目中的一部分(N=1800)我们将从理论上进行测试相互影响更大的知情多变量模型以及1)感染HTLV-III的较近的前驱 (通过ELISA法、免疫荧光法、培养法)，2)免疫缺乏数据(反映在分化标记研究中和功能测试)，3)行为的改变被确认与艾滋病病毒感染有关，以及4) 对请求对自我概念构成的威胁的回应提供血样，期待收到关于测试结果的信息、测试知识结果，以及与HTLV-III感染相关的症状，使用一系列多变量分析策略。我们的目标是进行以先前制定的一般规则为指导的四套分析的理论范式和综合述评文学。第一组模型中的解释因子包括非肠道药物使用，同性恋模式，如肛门接受性交，性乱交，以及增加学习和学习机会的心理社会因素变得有动力去参与这些模式。在第二个一组模型解释因素包括不同的模式药物滥用，心理社会压力，营养，其他健康状况指标和生物、心理和社会先兆在这些促进学习的因素中，动机参与或体验这些模式。这些因素是不是HTLV-III感染的直接或间接影响或其前体作用于免疫抑制状态。在第三盘在模型中，解释因素进一步包括对三个方面的后果及其主观评价意义事实上和/或被认为牵连的行为在艾滋病的发病和病程中的风险状况感染HTLV-III的人。第四盘在模型中，解释因素包括特征适应/应对/防御模式，个人和人际关系资源(工具资源和社会情感资源)，受威胁的社会角色的评估意义，以及对与艾滋病相关的潜在威胁刺激的认识，以及这些因素的前兆。