15AGRITECHCAT3 Innovative NextGen pig breeding using DNA sequence data

15AGRITECHCAT3 使用 DNA 序列数据的创新下一代猪育种

• 批准号: BB/N004736/1
• 负责人: John Hickey
• 金额: $ 149.1万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FN004736%2F1
• 关键词: 15AGRITECHCAT3; Innovative; NextGen; pig; breeding

SummaryIn this project, we will develop a new technology we call NextGen Breeding, which is based on the collection and utilization of very large quantities of sequence data, and will enable us to dramatically accelerate the rate of genetic improvement in our pig populations. This new technology will help us deliver real improvements to pig industry productivity and sustainability in the UK and around the world. The project involves collaboration between two world class UK partners, PIC (part of Genus plc), the world's leading pig breeding company and The Roslin Institute (RI), the world's leading research centre in the application of genomics and quantitative genetics to farm animal breeding. The project requires whole genome sequencing of samples on an unprecedented scale and even though our innovative approach dramatically reduces the costs over the conventional paradigm, the risk and costs are still considerable. Sharing the costs with Innovate UK would enable us to undertake this project.

在这个项目中，我们将开发一种新技术，我们称之为NextGen Breeding，它基于收集和利用大量的序列数据，并将使我们能够大大加快我们猪种群的遗传改良速度。这项新技术将帮助我们为英国和世界各地的养猪业生产力和可持续性提供真实的改善。该项目涉及两个世界级的英国合作伙伴，PIC（Genus plc的一部分），世界领先的养猪公司和罗斯林研究所（RI），世界领先的研究中心，在基因组学和定量遗传学的应用农场动物育种。该项目需要以前所未有的规模对样本进行全基因组测序，尽管我们的创新方法大大降低了传统模式的成本，但风险和成本仍然相当可观。与Innovate UK分担成本将使我们能够承担这个项目。

项目成果

MOESM1 of Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs

MOESM1 的基因驱动与基因组编辑增加牲畜育种计划遗传增益的潜力

• DOI: 10.6084/m9.figshare.c.3666634_d1
• 发表时间: 2017
• 作者: Gonen S

Effect of manipulating recombination rates on response to selection in livestock breeding programs.

• DOI: 10.1186/s12711-016-0221-1
• 发表时间: 2016-06-22
• 期刊: Genetics, selection, evolution : GSE
• 作者: Battagin M;Gorjanc G;Faux AM;Johnston SE;Hickey JM
• 通讯作者: Hickey JM

Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs.

• DOI: 10.1186/s12711-016-0280-3
• 发表时间: 2017-01-04
• 期刊: Genetics, selection, evolution : GSE
• 作者: Gonen S;Jenko J;Gorjanc G;Mileham AJ;Whitelaw CB;Hickey JM
• 通讯作者: Hickey JM

A hybrid method for the imputation of genomic data in livestock populations.

• DOI: 10.1186/s12711-017-0300-y
• 发表时间: 2017-03-03
• 期刊: Genetics, selection, evolution : GSE
• 作者: Antolín R;Nettelblad C;Gorjanc G;Money D;Hickey JM
• 通讯作者: Hickey JM

MOESM5 of A hybrid method for the imputation of genomic data in livestock populations

MOESM5 家畜种群基因组数据插补的混合方法

• DOI: 10.6084/m9.figshare.c.3708046_d5
• 发表时间: 2017
• 作者: AntolA­N R