RADIOPAQUE RESTORATIVE AND PROSTHETIC DENTAL RESINS

不透射线的修复和修复牙科树脂

• 批准号: 3219903
• 负责人: NIKHIL K SARKAR
• 金额: $ 7.48万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219903
• 关键词: barium; biomaterial evaluation; chelating agents; composite resins; contrast media; dental materials; ligands; polymers; resin

Polymer resins used to fabricate dental and medical prostheses and dental restorations are generally radiolucent. Thus they are difficult to locate when accidently or purposely introduced into the body. Therefore accidents pose a hazard to patients and often lead to several medical emergencies and occasionally death, while in every case radiographic diagnosis is difficult. The seriousness of these problems is becoming ever more widely recognized. Currently, radiopacity is accomplished with metal or heavy-metal salts or galsses. These additives weaken the mechanical integrity because of the disparity between the low polarity of a hydrophobic resin and the high polarity or ionic and metallic additives. It is proposed that lthis problem can be solved by incorporating neutral ligands which are strongly complexed with a heavy-metal ion such as Ba, thus solubilizing a metal salt in the resin and forming a homogenous structure that retains mechanical strength and resists liquid penetration. The macrocyclic "crown" ethers and "glymes", and the polyphosphonate esters are proposed as the chelating species to be investigated for carrying radiopaque salts. The study will be a collaboration between polymer scientists at S.U.N.Y., Syracuse, and Biomaterials, radiology, microbiology and tissue-culture scientists at L.S.U. School of Dentistry in New Orleans. The chelating polymers will be synthesized at S.U.N.Y., under separate grant support, and supplied to L.S.U. where they will be formulated as prosthetic and restorative resins and evaluated for radiodensity, mechanical integrity, and probable biological safety. Radiodensity will be determined by film densitometry of x-ray images of trial specimens. Mechanical integrity will be determined using tests and standards specified by American Dental Society specifications for restorative and prosthetic resins. Probable safety will be assessed using the Ames mutagenicity test and tissue culture cytotoxicity techniques developed at LSU. Funding is being sought via two companion applications. Each have identical research plans but different institutional information and budget requests. The budget requestin in this application is designed to completely support that part of the proposed investigation that is to be performed by the L.S.U. group.

用于制造牙科和医疗假体以及牙科的聚合物树脂 放射性同位素通常是放射性同位素。 因此，他们很难找到 当意外或故意引入体内时。 因此，事故 对患者造成危害，并经常导致几种医疗紧急情况， 偶尔死亡，而在每一个病例中， 难 这些问题的严重性正变得越来越广泛 认可. 目前，射线不透性是用金属或 重金属盐或玻璃。 这些添加剂削弱了 完整性，因为低极性之间的差距， 疏水性树脂和高极性或离子和金属添加剂。 本文提出，通过引入中性点， 与重金属离子如Ba， 从而将金属盐溶解在树脂中并形成均匀的 保持机械强度并防止液体渗透的结构。 大环“冠”醚和“甘醇二甲醚”，以及聚膦酸酯 被提议作为待研究的螯合物质来携带 不透射线的盐。 这项研究将是一个合作， 纽约大学的科学家，锡拉丘兹，生物材料，放射学，微生物学 和组织培养科学家牙科学校在新 奥尔良 螯合聚合物将在纽约州立大学合成，下 单独拨款支持并提供给洛杉矶州立大学where they will be 配制成假体和修复树脂， 放射密度、机械完整性和可能的生物安全性。 放射密度将通过X射线图像的胶片密度测定法测定， 试验样本。 机械完整性将通过测试和 美国牙科学会规定的标准 修复和假体树脂。 可能的安全性将使用 艾姆斯致突变试验和组织培养细胞毒性技术 在LSU开发。 目前正在通过两个配套应用程序寻求资金。 每个人都有相同的研究计划，但不同的机构信息 预算要求。 此应用程序中预算请求设计为 完全支持拟议调查的那部分， 由洛杉矶州立大学执行组