BIOLOGICAL MOLECULES IN THE CORROSION OF DENTAL ALLOYS

牙科合金腐蚀中的生物分子

• 批准号: 3220522
• 负责人: NIKHIL K SARKAR
• 金额: $ 11.4万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3220522
• 关键词: X ray crystallography; alloys; aminoacid; biomaterial evaluation; carbonates; chemical reaction; chlorine; dental amalgam; dental material wear; electrochemistry; electrolytes; metal dental material; nuclear magnetic resonance spectroscopy; organic chemicals; phosphates; saliva

Corrosion is the primary mechanism for the tarnish, toxicity and degradation of dental alloys. The long-term objective of this study is to define the mechanism of corrosion in the oral environment. The specific aims are: (1) to determine in vitro the possible role of relevant biological molecules in the corrosion of selected dental alloys, and (2) to identify and characterize the electrochemical reaction(s) in the above corrosion process. The corrosion behavior of dental amalgams, casting golds, silver-palladium and nickel-chromium alloys will be studied by potentiostatic and potentiodynamic polarization measurements in electrolytes containing individual biological molecules, singly or in combination. Biological molecules to be examined, in addition to the major components of saliva (namely, chloride, phosphate, carbonate, etc.) will include amino acids, poly-alpha-amino acids, polypeptides and proteins. Corroded alloy surfaces will be examined and analyzed by SEM, energy dispersive X-ray spectroscopy, X-ray diffraction, NMR and FTIR in order to define precisely the alloy-electrolyte interaction. Electrolytes will be analyzed by atomic absorption spectroscopy to determine the nature and concentration of metal ions released during corrosion. These studies will, in the long run, bring about a better understanding of the corrosion process of dental alloys in vivo and its possible contribution to clinical problems associated with toxicity, tarnishing and mechanical degradation.

腐蚀是导致变色、毒性和 牙科合金的降解。 这项研究的长期目标是 确定口腔环境中的腐蚀机制。 具体 目的是：（1）在体外确定相关的可能作用 生物分子在所选牙科合金的腐蚀中的作用，以及（2） 识别和表征上述电化学反应 腐蚀过程 牙科银汞合金、铸金、银钯合金的腐蚀行为 和镍铬合金将研究恒电位和 电解质中的动电位极化测量， 单独或组合的单个生物分子。 生物 除了唾液的主要成分外， （即氯化物、磷酸盐、碳酸盐等）将包括氨基酸， 聚-α-氨基酸、多肽和蛋白质。 腐蚀的合金表面将通过SEM、能量分析仪 分散X射线光谱、X射线衍射、NMR和FTIR，以便 精确定义合金-电解质相互作用。 电解质将是 通过原子吸收光谱法分析以确定性质， 腐蚀过程中释放的金属离子浓度。 从长远来看，这些研究将使人们更好地了解 牙科合金在体内的腐蚀过程及其可能性 导致与毒性、失泽和 机械降解