CORROSION OF PD CONTAINING DENTAL ALLOYS

含 PD 牙科合金的腐蚀

• 批准号: 2458642
• 负责人: NIKHIL K SARKAR
• 金额: $ 16.16万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458642
• 关键词: X ray spectrometry; alloys; biotransformation; chemical structure; cobalt; copper; corrosions; drug adverse effect; drug metabolism; electrochemistry; electrolytes; emission spectrometry; gallium; gold; hypersensitivity; metal dental material; oral facial restoration material; palladium; pharmacokinetics; saliva; scanning electron microscopy; silver; statistics /biometry; thermodynamics

The use of PdCu-based dental ceramic alloys has been linked to frequent incidence of allergy and hypersensitivity reactions. Whereas Pd has been suspected as the causative factor, the biological safety of other Pd- containing alloys has not been a matter of concern. The broad objective of this study is toe understand the reason why the PdCu-based alloy pose significantly greater risks to patients than some other alloys that also contain Pd. Corrosion is thought to play a major role in allergy and other alloys that also contain Pd. Corrosion is thought to play a major role in allergy and hypersensitivity. Therefore, a systematic study of the corrosion mechanism of selected Pd-containing alloys is proposed. The specific aims are (1) to study in vitro the corrosion behavior of 15 commercial and 9 experimental pd-containing alloys and their components in a synthetic saliva solution at 37 degrees Centrigrade, (2) to characterize the structural and compositional changes on the surface of these alloys due to corrosion, and (3) to determine the concentration of various metal ions released from these alloys during corrosion. The corrosion behavior will be studied by a number of electrochemical techniques and immersion tests. The electrochemical techniques will include (1) open-circuit-potential time measurement, (2) polarization corrosion test. Alloys subject to immersion and potentiostatic corrosion test will be examined and analyzed selectively by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS), to define the corrosion- induced structural and compositional changes on various surfaces. Electrolytes from immersion tests will be analyzed by the inductively coupled plasma emission spectroscopy (ICP-ES) technique to determine the nature and concentration of various cations eluted during corrosion. The data will be interpreted thermodynamically to identify the electrochemical mechanism(s) of corrosion. Statistical analysis of the data will be performed to determine the effects of alloy composition and structure and their interaction effects on various corrosion parameters and to describe the difference among alloys on the basis of these parameters. These studies will contribute to a better understanding of the corrosion process of these alloys in vivo, and its possible contribution to adverse biological reactions.a

PdCu基牙科陶瓷合金的使用与频繁的 过敏和超敏反应的发生率。 然而，Pd 怀疑是致病因素，其他Pd的生物安全性- 含有合金的材料并不是一个值得关注的问题。 的广泛目标 本研究旨在了解PdCu基合金 对患者的风险明显大于其他一些合金， 含有Pd。腐蚀被认为在过敏和其他疾病中起主要作用。 还含有钯的合金。腐蚀被认为在 过敏和超敏反应。 因此，系统研究 提出了所选含钯合金的腐蚀机理。 的 具体的目的是（1）在体外研究15 商业的和9个实验的含Pd合金及其组分 37摄氏度的合成唾液溶液，（2）表征 这些合金表面的结构和成分变化， （3）测定各种金属离子的浓度 从这些合金中释放出来。 腐蚀行为将 通过一些电化学技术和浸泡试验进行研究。 电化学方法包括（1）开路电位时间 （2）极化腐蚀试验。 易浸合金 并对恒电位腐蚀试验进行了重点考察和分析 通过扫描电子显微镜（SEM）、能量色散X射线光谱仪 (EDX)和X射线光电子能谱（XPS），以确定腐蚀- 在各种表面上引起结构和成分变化。 将通过感应分析仪分析浸泡试验中的电解质。 耦合等离子体发射光谱（ICP-ES）技术，以确定 腐蚀过程中洗脱的各种阳离子的性质和浓度。 的 将对数据进行分析，以确定电化学 腐蚀机制。 将对数据进行统计分析 进行测定合金成分和结构的影响， 它们对各种腐蚀参数的相互作用，并描述 合金之间的差异基于这些参数。 这些 研究将有助于更好地了解腐蚀过程 这些合金在体内，及其可能的贡献不利 生物反应. a