BIOLOGICAL MOLECULES IN THE CORROSION OF DENTAL ALLOYS

腐蚀是产生变色、毒性和腐蚀的主要机制 牙科合金的降解。这项研究的长期目标是 确定口腔环境中的腐蚀机制。具体的 目的是：(1)在体外确定相关蛋白的可能作用 生物分子对选定牙科合金的腐蚀，以及(2) 对上述电化学反应(S)进行鉴定和表征 腐蚀过程。 牙科银汞合金、铸金、银-钯的腐蚀行为 和镍铬合金将通过恒电位和 含盐电解液的动电位极化测量 单个生物分子，单独的或组合的。生物学 除了唾液的主要成分外，还需要检查分子 (即氯化物、磷酸盐、碳酸盐等)将包括氨基酸， 多-α-氨基酸、多肽和蛋白质。 对腐蚀后的合金表面进行扫描电子显微镜、能谱分析。 色散X射线光谱、X射线衍射、核磁共振和傅立叶变换红外光谱 准确定义合金-电解液的相互作用。电解液将是 用原子吸收光谱分析来确定性质和 腐蚀过程中释放的金属离子的浓度。 从长远来看，这些研究将使人们更好地理解 牙科合金在体内的腐蚀过程及其可能的机制 对临床问题的贡献，与毒性、变质和 机械降级。

Corrosion is the primary mechanism for the tarnish, toxicity and degradation of dental alloys. The long-term objective of this study is to define the mechanism of corrosion in the oral environment. The specific aims are: (1) to determine in vitro the possible role of relevant biological molecules in the corrosion of selected dental alloys, and (2) to identify and characterize the electrochemical reaction(s) in the above corrosion process. The corrosion behavior of dental amalgams, casting golds, silver-palladium and nickel-chromium alloys will be studied by potentiostatic and potentiodynamic polarization measurements in electrolytes containing individual biological molecules, singly or in combination. Biological molecules to be examined, in addition to the major components of saliva (namely, chloride, phosphate, carbonate, etc.) will include amino acids, poly-alpha-amino acids, polypeptides and proteins. Corroded alloy surfaces will be examined and analyzed by SEM, energy dispersive X-ray spectroscopy, X-ray diffraction, NMR and FTIR in order to define precisely the alloy-electrolyte interaction. Electrolytes will be analyzed by atomic absorption spectroscopy to determine the nature and concentration of metal ions released during corrosion. These studies will, in the long run, bring about a better understanding of the corrosion process of dental alloys in vivo and its possible contribution to clinical problems associated with toxicity, tarnishing and mechanical degradation.