COCAINE & EXERCISE: ROLE OF THE ADRENERGIC SYSTEM

可卡因

基本信息

  • 批准号:
    3209945
  • 负责人:
  • 金额:
    $ 13.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1988
  • 资助国家:
    美国
  • 起止时间:
    1988-04-01 至 1994-08-31
  • 项目状态:
    已结题

项目摘要

We recently observed that when cocaine is administered to rats prior to exercise it causes an exaggerated catecholamine response during exercise and a concomitant increase in glycogen degradation in muscle. These findings have practical relevance for exercise performance as well as health implications. Because this field of study (cocaine and exercise) has received little scientific attention, we wish to pursue our research goals further. this proposal has two general objectives. The first is to gain further insight into the combined physiological effects of cocaine and exercise. Using the cocaine-exercise-rat model (30 min of treadmill exercise after IV cocaine, 1-5 mg/kg) we plan to answer the following questions: 1) Are the effects of cocaine during exercise a function of the intensity of exercise? 2) What are the effects of chronic cocaine on adaptations to endurance training? 3) Does exercise training attenuate the effects of cocaine? and 4) Are the effects of cocaine similar to those of amphetamine? The second objective is mechanistic in nature and involves identifying how cocaine exerts its peripheral effects. This will be accomplished by exposing the animals to various perturbations such as adrenal enervation, adrenodemedullation, sympathectomy, and alpha and beta adrenoceptor antagonists and then exercising them under the influence of cocaine as described above. The normal rise in plasma catecholamine and the increase rate of glycogenolysis will serve as the criteria of measure in these studies. the results should clarify 1) whether the catecholamine response to cocaine is centrally mediated, peripherally mediated, or both, and 2) whether the rapid muscle glycogenolysis is linked to the cocaine- induced elevation in plasma catecholamine levels. Because knowledge concerning the peripheral effects of cocaine is severely lacking, the results from this proposal coupled with those from our first project will continue to fill the void. Eventually, we hope to extend our observations to the subcellular level using the tools of molecular biology, but we must cover this important ground first.
我们最近观察到,当可卡因在大鼠体内注射之前 运动它会在运动中引起夸大的儿茶酚胺反应 随之而来的是肌肉中糖原降解的增加。这些 研究结果对运动成绩以及 对健康的影响。因为这个研究领域(可卡因和锻炼) 几乎没有受到科学的关注,我们希望继续我们的研究 再进一球。这项提议有两个总体目标。第一个是 进一步了解可卡因和可卡因的联合生理效应 锻炼身体。使用可卡因-运动-大鼠模型(30分钟跑步机 运动后静脉注射可卡因,1-5毫克/公斤)我们计划回答以下问题 问题:1)运动中可卡因的作用是不是 运动强度?2)慢性可卡因对健康有什么影响? 对耐力训练的适应?3)运动训练是否会减弱 可卡因的影响?以及4)可卡因的影响是否与 安非他命?第二个目标本质上是机械性的,涉及 确定可卡因是如何发挥其外围效应的。这将是 通过将动物暴露在各种扰动中来实现,例如 肾上腺神经支配、肾上腺去髓质、交感神经切除、α和β 肾上腺素受体拮抗剂,然后在影响下锻炼它们 如上所述的可卡因。血浆儿茶酚胺和 糖原分解速率的增加将作为衡量标准 在这些研究中。这一结果应该能澄清1)儿茶酚胺 对可卡因的反应是中枢调节的,也可以是外围调节的,或者两者兼而有之, 2)肌肉快速糖原分解是否与可卡因有关- 诱导性血浆儿茶酚胺水平升高。因为知识 关于可卡因的外周作用严重缺乏, 这个提案的结果加上我们第一个项目的结果将 继续填补这一空白。最终,我们希望扩大我们的观察范围 到亚细胞水平,使用分子生物学的工具,但我们必须 首先覆盖这一重要领域。

项目成果

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ROBERT K CONLEE其他文献

ROBERT K CONLEE的其他文献

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{{ truncateString('ROBERT K CONLEE', 18)}}的其他基金

EFFECTS OF COCAINE ON THE PHYSIOLOGY OF EXERCISE
可卡因对运动生理学的影响
  • 批准号:
    3209943
  • 财政年份:
    1988
  • 资助金额:
    $ 13.56万
  • 项目类别:
EFFECTS OF COCAINE ON THE PHYSIOLOGY OF EXERCISE
可卡因对运动生理学的影响
  • 批准号:
    3209947
  • 财政年份:
    1988
  • 资助金额:
    $ 13.56万
  • 项目类别:
EFFECTS OF COCAINE ON THE PHYSIOLOGY OF EXERCISE
可卡因对运动生理学的影响
  • 批准号:
    3209948
  • 财政年份:
    1988
  • 资助金额:
    $ 13.56万
  • 项目类别:
COCAINE & EXERCISE: ROLE OF THE ADRENERGIC SYSTEM
可卡因
  • 批准号:
    2117166
  • 财政年份:
    1988
  • 资助金额:
    $ 13.56万
  • 项目类别:
COCAINE & EXERCISE: ROLE OF THE ADRENERGIC SYSTEM
可卡因
  • 批准号:
    3209949
  • 财政年份:
    1988
  • 资助金额:
    $ 13.56万
  • 项目类别:
EFFECTS OF COCAINE ON THE PHYSIOLOGY OF EXERCISE
可卡因对运动生理学的影响
  • 批准号:
    3895362
  • 财政年份:
  • 资助金额:
    $ 13.56万
  • 项目类别:
EFFECTS OF COCAINE ON PHYSIOLOGY OF EXERCISE
可卡因对运动生理学的影响
  • 批准号:
    3873434
  • 财政年份:
  • 资助金额:
    $ 13.56万
  • 项目类别:

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