EFFECTS OF COCAINE ON THE PHYSIOLOGY OF EXERCISE

可卡因对运动生理学的影响

• 批准号: 3209943
• 负责人: ROBERT K CONLEE
• 金额: $ 8.49万
• 依托单位: BRIGHAM YOUNG UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3209943
• 关键词: bioenergetics; biological models; catecholamines; central nervous system stimulants; cocaine; dosage; drug addiction; exercise; glucagon; glucocorticoids; glycogen; heart metabolism; insulin; laboratory rat; liver metabolism; muscle metabolism; physiology; sports medicine; sympathetic nervous system

The use of cocaine as an illegal drug is reaching epidemic proportions. Yet, the physiological and biochemical effects of the drug are poorly understood. This is especially true in relation to exercise physiology in spite of the widespread use of this drug among competitive athletes as well as recreational participants. The hazards encountered by users of cocaine prior to exercise have not been described, but it can be speculated that, since cocaine and exercise both act to enhance the sympathetic system, such an additive effect could have serious consequences on all physiological systems under sympathetic control such as muscle blood flow, substrate mobilization and utilization, myocardial metabolism, liver metabolism, as well as endocrine function. There is virtually no information regarding the effects of cocaine on these physiological systems either at rest or during exercise. Thus, the purpose of this project is to use the exercising rat model as a tool for studying 1) the effects of various doses of cocaine on resting physiology (dose-response), 2) the effects of various doses on the physiological response to exercise, 3) the effect of various doses on cardiac metabolism during exercise, 4) the chronic effects of cocaine use (addiction) on the acute response to exercise, and 5) the chronic effects of cocaine use on the normal adaptive response to endurance training. Parameters to be assessed ineach of these studies include 1) liver and muscle glycogen metabolism, 2) blood substrate changes (FFA, glucose, lactic acid), and 3) hormonal changes (catecholamines, glucagon, insulin, glucocorticoid). In addition glucose-6-phosphate and citrate levels will be measured in heart. The effects on certain aerobic and anaerobic enzymes will also be examined in the training studies. It seems logical to evaluate the physiology of cocaine using the exercise model, since exercise creates such marked alteration in a number of physiological systems. Fortunately, these alterations are well characterized, and thus can serve as markers for any effects of cocaine. Furthermore, cocaine has the reputation of being a performance enhancer, yet this belief is based on superficial data, very little of which is physiological. For these purposes the study of cocaine and exercise seems to be extremely important. This project could provide valuable information that could be used as a basis for future studies to investigate the mechanism by which cocaine might exert its effects peripherally. Such would be our long range research goal.

可卡因作为一种非法药物的使用正在蔓延。 比例。然而，这些物质的生理和生化效应 人们对药物知之甚少。这一点在涉及到 运动生理学，尽管这种药物被广泛使用 在竞技运动员和娱乐参与者中。 可卡因使用者在运动前遇到的危险 没有被描述过，但可以推测，因为 可卡因和锻炼都能增强交感系统， 这种相加效应可能对所有人产生严重后果 交感神经控制下的生理系统，如肌肉 血流、底物动员和利用、心肌 代谢，肝脏代谢，以及内分泌功能。 几乎没有关于可卡因的影响的信息。 在这些生理系统上，无论是休息时还是运动时。 因此，本项目的目的是使用运动大鼠模型 作为研究1)不同剂量可卡因对人的影响的工具 静息生理学(剂量-反应)，2)不同剂量的影响 关于运动的生理反应，3)不同运动方式的影响 运动时心脏代谢的剂量，4)慢性 可卡因的使用(成瘾)对急性反应的影响 运动，以及5)使用可卡因对正常人的慢性影响 对耐力训练的适应性反应。参数应为 这些研究中的每一项评估包括1)肝脏和肌肉 糖原代谢，2)血底物改变(FFA，葡萄糖， 乳酸)和3)激素变化(儿茶酚胺、胰高血糖素、 胰岛素、糖皮质激素)。此外，葡萄糖-6-磷酸和 柠檬酸水平将在心脏中进行测量。对某些人的影响 有氧酶和厌氧酶也将在 培训研究。这似乎是合乎逻辑的评估生理学 使用运动模式的可卡因，因为运动产生了 许多生理系统发生了明显的变化。 幸运的是，这些变化有很好的特征，因此 可以作为可卡因的任何影响的标记。此外， 可卡因有提高成绩的美誉，但 这种看法是建立在肤浅的数据基础上的，其中很少有 生理上的。为此目的，可卡因和可卡因的研究 锻炼似乎是极其重要的。这个项目可以 提供有价值的信息，可用作 未来研究可卡因的作用机制 可能会在外围发挥作用。这将是我们的远距离飞行 研究目标。