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Developmental Tuning of Turing Patterning

图灵模式的发展调整

基本信息

批准号：
BB/N008545/1
负责人：
Denis Headon
金额：
$ 45.02万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FN008545%2F1
关键词：
Developmental Tuning Turing Patterning

项目摘要

Our bodies arrange their own parts appropriately before we are born. We have only one of certain body parts (e.g. head, nose, spleen) and two of others (e.g. arm, eye, big toe) of, and these achieve their position through an equivalent of an embryo's Global Positioning System. However, still other structures, like hairs or nephrons of the kidney, are very numerous - too numerous to have a dedicated placing of each and every one of them. Instead, the body seems to use a simple "rule" to lay out these structures. This "rule" involves local interactions between cells which make sure that each follicle, nephron, or other structure, forms at a set distance from others of the same kind. Theoretical biologists have provided and proven general concepts that could underlie the operation of these "rules" and recent work by molecular biologists has substantiated and extended these theoretical ideas, identifying the specific genes and proteins that act as to set the "rule".However, structures like hair follicles are not homogeneous across the body. For example, the eyebrows and scalp produce thicker hair types that mark these parts of the skin as being different from, for example, the forehead, which has very small, fine hairs. In this proposal we aim to understand how such distinctions in pattern, in this case of hair follicles serving as an example of other repeated structures, can be achieved. In essence, we will go up one level in organisation to understand how the size and spacing "rule" can be varied in different locations. This we will do by studying hair follicle formation on different parts of the mouse skin, with a focus on the various whiskers because of their distinctive pattern. Our project will be a combination of molecular and cell biology in analysing and manipulating the signals that pass between cells and mathematical simulations to interpret and guide the experimentation. Experiments will be done primarily on cultured skin samples, sparing use of intact animals. The intended outcome is to understand at both molecular and conceptual levels how the body can utilise a single pattern forming system by tuning in different regions to achieve a complex anatomy.

我们的身体在我们出生之前就已经安排好了自己的部分。我们只有一个特定的身体部位（如头部，鼻子，脾脏）和其他两个（如手臂，眼睛，大脚趾），这些通过相当于胚胎的全球定位系统来实现它们的位置。然而，还有其他结构，如肾脏的毛发或肾单位，数量非常多-太多了，无法将它们中的每一个都专门放置。相反，身体似乎使用一个简单的“规则”来布局这些结构。这个“规则”涉及到细胞之间的局部相互作用，确保每个滤泡、肾单位或其他结构与其他同类的结构保持一定的距离。理论生物学家已经提供并证明了这些“规则”运作的基础的一般概念，分子生物学家最近的工作已经证实并扩展了这些理论思想，确定了设置“规则”的特定基因和蛋白质。例如，眉毛和头皮产生较厚的毛发类型，其标记皮肤的这些部分不同于例如具有非常小的细毛的前额。在这个建议中，我们的目标是了解如何在模式上的这种区别，在这种情况下，毛囊作为其他重复结构的一个例子，可以实现。从本质上讲，我们将在组织中上升一个层次，以了解大小和间距“规则”如何在不同的位置变化。我们将通过研究小鼠皮肤不同部位的毛囊形成来做到这一点，重点是各种胡须，因为它们有独特的图案。我们的项目将结合分子和细胞生物学，分析和操纵细胞之间传递的信号，并进行数学模拟来解释和指导实验。实验将主要在培养的皮肤样本上进行，保留使用完整的动物。预期的结果是在分子和概念水平上理解身体如何通过在不同区域进行调谐来利用单一模式形成系统以实现复杂的解剖结构。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Modelling bodyweight to avoid anthelmintic underdosing of goats in resources-limited settings.

DOI：
10.1007/s11250-023-03479-6
发表时间：
2023-02-09
期刊：
TROPICAL ANIMAL HEALTH AND PRODUCTION
影响因子：
1.7
作者：
Evans, M. J.;Kaona, C. L.;Barros, A. K.;Bailey, J. L. Burdon;Chikungwa, P.;Costa-Junior, L. M.;Gamble, L.;Hopker, A. M.;Kelly, R. F.;Lohr, F.;Silva, R.;Sargison, N. D.
通讯作者：
Sargison, N. D.

Modelling Bodyweight to Avoid Anthelmintic Underdosing of Goats in Resources Limited Settings

建立体重模型以避免资源有限环境下山羊驱虫药剂量不足

DOI：
10.21203/rs.3.rs-1878322/v1
发表时间：
2022
期刊：
影响因子：
0
作者：
Evans M
通讯作者：
Evans M

Systems for intricate patterning of the vertebrate anatomy.

DOI：
10.1098/rsta.2020.0270
发表时间：
2021-12-27
期刊：
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
影响因子：
0
作者：
Painter KJ;Ptashnyk M;Headon DJ
通讯作者：
Headon DJ

Hierarchical patterning modes orchestrate hair follicle morphogenesis.

分层图案模式编排毛囊形态发生。

DOI：
10.1371/journal.pbio.2002117
发表时间：
2017-07
期刊：
PLoS biology
影响因子：
9.8
作者：
Glover JD;Wells KL;Matthäus F;Painter KJ;Ho W;Riddell J;Johansson JA;Ford MJ;Jahoda CAB;Klika V;Mort RL;Headon DJ
通讯作者：
Headon DJ

Limb development genes underlie variation in human fingerprint patterns.

肢体发育基因是人类指纹模式变异的基础

DOI：
10.1016/j.cell.2021.12.008
发表时间：
2022-01-06
期刊：
Cell
影响因子：
64.5
作者：
Li J;Glover JD;Zhang H;Peng M;Tan J;Mallick CB;Hou D;Yang Y;Wu S;Liu Y;Peng Q;Zheng SC;Crosse EI;Medvinsky A;Anderson RA;Brown H;Yuan Z;Zhou S;Xu Y;Kemp JP;Ho YYW;Loesch DZ;Wang L;Li Y;Tang S;Wu X;Walters RG;Lin K;Meng R;Lv J;Chernus JM;Neiswanger K;Feingold E;Evans DM;Medland SE;Martin NG;Weinberg SM;Marazita ML;Chen G;Chen Z;Zhou Y;Cheeseman M;Wang L;Jin L;Headon DJ;Wang S
通讯作者：
Wang S