INPUT/OUTPUT PROPERTIES OF A MAPPED SENSORY SYSTEM

映射传感系统的输入/输出属性

• 批准号: 3216973
• 负责人: JOHN Pratt MILLER
• 金额: $ 10.75万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1992-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3216973
• 关键词: Orthoptera; afferent nerve; central nervous system; dendrites; interneurons; mechanoreceptors; microelectrodes; neural information processing; noise biological effect; sensory feedback; sensory mechanism; sensory thresholds; sound frequency; stimulus /response; synapses

The goal of this research project is to determine how a relatively complex sensory system extracts and encodes information from external stimuli. The response properties of the system will be observed and characterized at two levels: at the receptor level and at the output layer to higher CNS levels. During some experiments, the responses from all of the cells in the output layer will be monitored simultaneously. Analysis of this data will provide a complete description of the input/output properties and encoding algorithm of this system. The preparation to be studied is the cercal sensory system of the cricket, Acheta domesticus. Crickets (and many other insects) have two antenna-like appendages at the rear of their abdomen, covered with hundreds of "filiform" hairs, resembling bristles on a bottle brush. Deflection of these filiform hairs by wind currents activates mechanosensory receptors, which project into the terminal abdominal ganglion to form a topographic representation (or "map") of "wind space". Primary sensory interneurons having dendritic branches within this afferent map of wind space are selectively activated by wind stimuli with "relevant" parameters, and generate action potentials at frequencies that depend upon the value of those parameters. The "relevant" parameters are thought to be the direction, velocity, and acceleration of wind currents directed at the animal. There are only ten pairs of these interneuons which carry the system's output to higher centers. All ten of these output units are identified, and all will be monitored simultaneously with extracellular electrodes. The following specific questions will be addressed: What are the response properties of th sensory receptors, and what are the I/O properties of the receptor layer as a whole? What are the response properties of all the units in the output layer? Is all of the direction, velocity and acceleration information that is extracted at the receptor layer also available at the output layer? How is that information encoded? Are any higher order "features" also encoded? What is the overall threshold, sensitivity and dynamic range of the system as a whole for detecting features of wind stimuli? An attempt will be made to assess how all of the observed properties relate to the structure of the output neurons, the synaptic connectivity of the output interneurons with other local interneurons, and the synaptic connectivity of the output neurons with the sensory afferents in the map of wind space.

这个研究项目的目标是确定一个相对 复杂的感觉系统提取和编码信息， 外部刺激。 系统的响应特性将是 在两个层面上观察和表征：在受体层面上 并且在输出层处达到更高的CNS水平。 在一些 实验中，输出中所有细胞的响应 将同时监测层。 对这些数据的分析将 提供输入/输出属性的完整描述， 本系统的编码算法。 所研究的制剂是小鼠的尾部感觉系统。 蟋蟀Acheta acuticus 蟋蟀（和许多其他昆虫） 在腹部后部有两个触角状的附属物， 覆盖着数以百计的“丝状”毛发，类似于 瓶刷 这些丝状的毛发被气流偏转 激活机械感受器， 末端腹神经节，以形成地形图表示 (or“风空间”的“地图”）。 初级感觉中间神经元， 在风空间的传入地图中的树枝状分支是 通过具有“相关”参数的风刺激选择性地激活， 产生动作电位的频率取决于 这些参数的值。 “相关”参数是 被认为是风的方向、速度和加速度 电流直接作用于动物。 只有十双 将系统的输出传送到更高中心的中间中子。 所有这十个输出单元都被识别出来， 与细胞外电极同时监测。 的 将讨论以下具体问题： 感觉受体的反应特性，以及I/O是什么 感受器层的整体特性？ 有哪些 输出层中所有单元的响应属性？ 是所有 方向、速度和加速度信息， 在接收器层提取，也可在输出层？ 这些信息是如何编码的？ 有没有更高级的 “特征”也被编码？ 总体阈值、灵敏度是多少 和动态范围的系统作为一个整体， 风的刺激特征？ 将尝试评估如何 所有观察到的属性都与输出的结构有关 神经元，输出中间神经元与 其他本地interneurons，和突触连接的 输出神经元与感觉传入神经元在风的地图 空间