NEONATAL DEVELOPMENT OF AUDITORY RESPONSIVENESS

这项研究计划的目标仍然是一个 全面、系统和参数化评估， 在适当的动物模型中发展听觉感知。 通过 能够在一个 发展新生儿，我们希望能大大扩展知识， 听觉的正常发展，并与 其他生理学和解剖学研究，极大地扩展了我们的 关于结构与功能之间关系的知识 发育中的听觉系统 该提案的主要部分继续受到控制 心理物理学的研究，各种阈值如何变化， 出生后的头几天 自适应程序和信号 检测分析将用于评估频率和 新生儿的时间分辨率。 具体来说，这些实验 包括同频、陷波噪声和限带掩蔽 功能;间隙检测、频率调制和幅度- 调制阈值;强度差阈值;和绝对值 对自然主义刺激的阈值。 第二部分继续使用多维 缩放程序，以产生新生儿如何应对的“地图” 更复杂的听觉刺激 总之，这些实验提供了一个独特的和有价值的 有机会仔细记录听觉感知的变化， 正在发育的新生儿 除了为我们的 了解正常的听力，这项研究计划应该 也有助于我们了解异常发育如何导致 沟通障碍

The objective of this research program continues to be a comprehensive, systematic, and parametric evaluation of developing auditory perception in an appropriate animal model. By being able to make careful psychoacoustical measures in a developing neonate we hope to greatly extend knowledge about the normal development of auditory perception, and by comparison with other physiological and anatomical research, greatly extend our knowledge about the relationship between structure and function in the developing auditory system. The main section of this proposal continues controlled psychophysical studies of how various thresholds change over the first few postnatal days. Adaptive procedures and signal detection analyses will be used to evaluate both frequency and temporal resolution in neonates. Specifically, these experiments involve tone-on-tone, notched-noise, and band-limited masking functions; gap-detection, frequency-modulation, and amplitude- modulation thresholds; intensity difference limens; and absolute thresholds to a naturalistic stimulus. A secondary section continues experiments that use multidimensional scaling procedures to produce "maps" of how neonates respond to more complex auditory stimuli. In conclusion, these experiments provide a unique and valuable opportunity to carefully document changing auditory perceptions in a developing neonate. In addition to contributing to our understanding of normal hearing this program of research should also help us understand how abnormal development may lead to communicative disorders.