MIXTURE INTERACTIONS IN OLFACTION

嗅觉中的混合物相互作用

• 批准号: 3216532
• 负责人: CHARLES D DERBY
• 金额: $ 8.43万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3216532
• 关键词: Malacostraca; biological models; eating; electrophysiology; hippocampus; interneurons; ligands; limbic system; mathematical model; neural information processing; neuroanatomy; neurophysiology; olfactions; olfactory stimulus; saltwater environment; stimulus /response

The long-term objective of this project is to discover basic principles concerning the detection and discrimination of odorant mixtures and their componets. The focus of this research will been responses to bianry odorant mixture, which will serve as a model for more complex mixtures. A common observation in studies of mixtures of odorant or tastants is that responses to mixtures are often not predictable, even when thresponses to the individual components of the mixtures are known. These phenomena, termed mixture interactions, are widespread, occurring in humans as well as lower animals. The proposed project uses as the experimental animal model the spiny lobster Panulirus argus, which has proven to be an excellent system for studies of olfaction, including mixture interactions and behavioral and neural aspects of quality coding. The specific aims of this project are to: (1) identify and characterize olfactory mixture interactions for binary odorant mixtures; and (20 evaluate the effects of mixture interactions on behavioral and neural discrimination of the quality of banner odorant mixtures. Mixture interactions will be identified and characteri by appealing behavioral models of ligand-receptor binding. The effects of mixture interactions on discrimination of quality of bianry odorant mixtures and their components will be described btu evaluating quality discrimination for bianry mixtures containing componets that door do not show mixture interactions, using previously developed techniques;: multivariate analysis of single-unit neurophysiological data from olfactory receptor cells and olfactory brain interneurone for neural discrimination; multivariate analysis of results of differential aversive conditioning for behavioral discrimination.

该项目的长期目标是发现基本的 气味物检测和鉴别原理 混合物及其组分。 这项研究的重点将是 反应bianry气味混合物，这将作为一个模型 更复杂的混合物。 研究中的一个常见观察结果是， 气味剂或味觉剂的混合物的一个重要特征是， 通常是不可预测的，即使是对个人的反应， 混合物的组分是已知的。 这些现象被称为 混合物的相互作用，是广泛的，发生在人类以及 作为低等动物。 该项目作为实验项目， 动物模型是棘龙虾Panulirus argus， 是一个优秀的系统研究嗅觉，包括 质量的混合互动和行为及神经方面 编码 该项目的具体目标是：（1）确定和 表征二元气味剂的嗅觉混合物相互作用 混合物;和（20）评估混合物相互作用对 旗帜质量的行为和神经辨别 气味混合物。 将识别混合物相互作用， 通过吸引配体-受体的行为模型 约束力 混合物的相互作用对识别的影响 气味剂混合物及其组分的质量将 所述BTU评价混合物的质量区分度 含有不显示混合物相互作用的组分， 使用先前开发的技术;： 来自嗅觉感受器细胞的单单位神经生理学数据 嗅脑神经元用于神经辨别; 差异厌恶结果的多元分析 行为歧视的条件反射。