Preventing chromosome segregation errors in anaphase

防止后期染色体分离错误

• 批准号: BB/P020771/1
• 负责人: Jonathan Higgins
• 金额: $ 45.64万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP020771%2F1
• 关键词: Preventing; chromosome; segregation; errors; anaphase

To sustain life, cells must be able to divide into two genetically identical daughters. During cell division, chromosomes must be precisely apportioned into the two daughter cells so that all the genetic information remains intact. Although surveillance mechanisms exist to ensure the accuracy of this process, errors can occur. These errors can lead to cells with the wrong numbers of chromosomes and to birth defects, miscarriage, cancer and ageing. One of the key proteins involved in error correction is an enzyme known as Aurora B, and work from many laboratories has shown that Aurora B acts early during cell division to minimise mistakes. However, it is clear that the error correction machinery is not foolproof, and certain types of error are not detected during the early stages of cell division. The aim of this project is to understand how cells deal with persistent errors and, in particular, to determine how Aurora B regulates chromosome sorting during the late stages of cell division to make sure that accurate inheritance of genetic material is maintained.

为了维持生命，细胞必须能够分裂成两个基因相同的子代。在细胞分裂过程中，染色体必须精确地分配到两个子细胞中，以便所有的遗传信息保持不变。虽然存在监督机制来确保这一过程的准确性，但也可能发生错误。这些错误可能会导致细胞的染色体数量错误，并导致出生缺陷、流产、癌症和衰老。参与纠错的关键蛋白质之一是一种名为Aurora B的酶，许多实验室的研究表明，Aurora B在细胞分裂的早期采取行动，将错误降至最低。然而，很明显，纠错机制并不是万无一失的，某些类型的错误在细胞分裂的早期阶段没有被检测到。该项目的目的是了解细胞如何处理持续性错误，特别是确定Aurora B如何在细胞分裂的后期调节染色体分选，以确保保持遗传物质的准确遗传。

项目成果

The Aurora B gradient sustains kinetochore stability in anaphase.

• DOI: 10.1016/j.celrep.2021.109818
• 发表时间: 2021-11-09
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Papini D;Levasseur MD;Higgins JMG
• 通讯作者: Higgins JMG