HUMAN GASTRIC PHYSIOLOGY IN HEALTH AND DISEASE

本提案的具体目标集中在四个关键调查领域 在人身上1.胃肠营养素控制 禁食-进食-禁食运动序列 2.餐后营养与 压力活动和胃排空液体和固体。 3.中央 餐后胃功能的神经系统控制，特别是 通过研究应激引起的胃动力紊乱， 饭后分泌物 4.参与的病理生理机制 上消化道功能性疾病。 这些具体 目标被整合到一个逻辑序列中。 从一个基地开始， 我们将添加某些新的程序和地址 与人类胃功能控制有关的悬而未决的问题。 这些实验的核心是食物性质的影响（在 特别是生理状态和营养成分）对胃运动的影响 具体目标1和2）。 需要这些研究来调查 进一步强调对人类肠道的影响，并解决调解 这些影响通过中枢神经系统（具体目标3）。 最后，我们将通过调查， 胃功能可能的病理生理异常及其 功能障碍患者的中枢控制（具体目标4）。

The Specific Aims of this proposal focus on four key areas of investigation in man. 1. Control by nutrients of the gastrointestinal fasting-fed-fasting motor sequence. 2. Relations among postprandial pressure activity and gastric emptying of liquids and solids. 3. Central nervous system control of postprandial gastric function, specifically through the study of stress-induced perturbations of gastric motility and secretion after meals. 4. Pathophysiological mechanisms involved in functional diseases of the upper gastrointestinal tract. These Specific Aims are integrated into a logical sequence. Starting from a base of established methods we will add certain novel procedures and address outstanding questions related to the control of gastric functions in man. Central to these experiments is the influence of the nature of food (in particular the phsical state and nutrient composition) on gastric motor activity (Specific Aims 1 and 2). These studies are needed to investigate further the effects of stress on the human gut and to address the mediation of these effects through the central nervous system (Specific Aim 3). Finally, we will bring together the preceding projects by investigating possible pathophysiological abnormalities of gastric function and its central control in patients with functional disorders (Specific Aim 4).