MOTILITY AND TRANSIT ACROSS THE ILEO-CECAL SPHINCTER

回肠-结肠连接部在调节中枢神经系统功能中的作用 胃肠道几乎没有受到关注，尽管有很多 以表明这个交界区具有重要的功能。因此， 大肠的正常反应能力，通过将食糜转化为 形成的大便，受鲁米那的质量和数量的影响 到达近端结肠的内容物。一般的假设是 回肠远端、回结肠括约肌和近端结肠起作用 共同作为一个协调的节段来调节从回肠到结肠的运输； 此外，这些机制的适当运作大大有助于 远端肠道的正常功能。 回结肠连接部信息相对缺乏的原因 包括该地区的不可访问性。在最初的资助期 在这笔赠款中，已经开发出允许回结肠 狗和人的交界处将被调查。进一步的方法论 这里提出了一些方法，并扩展了以前的研究。 它将讨论控制运动和运输的机制 该地区。 这里描述的实验有以下具体目标： 1.利用已建立的、特征良好的犬模型 评估回盲肠运动和转运的控制情况。的角色 神经肽和药理药剂将被检测。 2.改进回盲肠运动和运输的方法 在MAN中进行量化和关联，并进一步评估对 人的回盲肠功能。 3.明确回结肠动力障碍的作用 胃肠道疾病的症状。 这里概述的工作应该直接适用于更好的 了解几种常见的胃肠道疾病；包括 吸收不良综合征，非特异性腹泻，肠易激综合征， 以及胃肠道手术后的术后生理学。

The role of the ileo-colonic junction in modulating performance of the gastrointestinal tract has received little attention, though there is much to suggest that this junctional region has important functions. Thus, the capacity of the large bowel to respond normally, by converting chyme to formed stools, is influenced by the quality and quantity of luminal contents arriving in the proximal colon. The general hypothesis is that the distal ileium, ileocolonic sphincter (ICS) and proximal colon act together as a coordinated segment to regulate transit from ileum to colon; moreover, proper functioning of these mechanisms contributes significantly to normal performance of the distal bowel. Reasons for the relative lack of information on the ileocolonic junction include the inaccessability of the region. In the initial funding period of this grant, methods have been developed which allow the ileocolonic junction to be investigated in dog and man. Further methodological approaches are proposed here together with extensions of earlier studies which will address the mechanisms for control of motility and transit in the region. The experiments described here have the following Specific Aims: 1. To utilize an established and well-characterized canine model to evaluate control of ileocecal motility and transit. The roles of neuro-peptides and pharmacologic agents will be examined. 2. To refine methods by which ileocecal motility and transit can be quantified and correlated in man, and to further evaluate the control of ileocecal function in man. 3. To establish the role of disorders of ileocolonic motility in defined syndromes of gastrointestinal disease. The work outlined here should have direct application to the better understanding of several common gastrointestinal diseases; these include malabsorption syndromes, non-specific diarrhea, irritable bowel syndrome, and the postoperative physiology that follows gastrointestinal surgery.