MOTILITY AND TRANSIT ACROSS THE ILEO-CECAL SPHINCTER

回肠和结肠之间的连接处符合传统的诊断标准 被归类为括约肌(回肠盲肠括约肌；ICS)；它表现出 随着近端扩张而放松的高压区，与 远端扩张，并有肌肉，在 体外培养。然而，ICS的生理和功能作用在 控制从小肠到大肠的乳糜流已经收到了 很少有人注意到。然而，通过规范内容进入 结肠，ICS可能是结肠功能的重要决定因素， 与以结肠功能障碍为特征的疾病有关。我们有 开发了一种犬科制剂，可以长期记录 回肠和ICS的电控制活动与 腔内压力的变化；我们将使用括约肌“袖状探头” 用于记录ICS紧张压。一系列平行的研究将是 在完整的MAN中表演，我们将在MAN回肠和ICS中记录 压力。一个主要的目标是建立时间相关性 消化间期肌电活动(IMC)与压力 在ICS运作的部队。此后，这些潜在的推进器 阻滞力将需要与液体的运输和 固体穿过回肠和ICS。我们的最终目标是 建立健康的回结肠转运控制机制，以 为评价受扰功能之间的关系奠定基础 ICS对人类疾病的影响。我们还希望研究在哪些方面 ICS的功能可能会被修改，以获得潜在的治疗益处。

The junction between the ileum and colon fufills conventional criteria for classification as a sphincter (ileo-cecal sphincter; ICS); it exhibits a high pressure zone which relaxes with proximal distention, contracts with distal distention and has muscle which displays specialized functions in vitro. However, the physiology and functional role of the ICS in controlling the flow of chyme from small to large intestines have received little attention. And yet, by regulating the entry of contents into the colon, the ICS could by an important determinant of colonic function and be relevant to diseases characterized by colonic dysfunction. We have developed a canine preparation which allows long term recording of electrical control activity in the ileum and ICS in association with changes in intraluminal pressures; we will use a sphincteric "sleeve probe" for recording ICS tonic pressure. A parallel series of studies will be performed in intact man, we will record in man ileocolonic and ICS pressures. A major aim is to establish the temporal correlations among interdigestive myoelectrical control activity (IMC's) and the pressure forces that operate at the ICS. Thereafter, these potentially propulsive and retarding forces will need to be integrated with transit of liquids and solids through the ileum and across the ICS. Our ultimate goal is to establish the mechanisms that control ileocolonic transit in health so as to develop a basis for evaluating the relationships of disturbed function of the ICS to human disease. We also wish to examine ways in which functions of the ICS might be modified for potential therapeutic benefits.