MOTILITY AND TRANSIT ACROSS THE ILEO-CECAL SPHINCTER

回肠括约肌的运动和运输

• 批准号: 3230582
• 负责人: SIDNEY F PHILLIPS
• 金额: $ 14.17万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3230582
• 关键词: colon; colon disorder; diarrhea; dietary lipid; digestion; disease /disorder model; electromyography; gastrointestinal absorption /transport; gastrointestinal disorder diagnosis; gastrointestinal motility /pressure; gastrointestinal pharmacology; ileocolonic region; ileum; intestinal mucosa; ion transport; irritable bowel syndrome; malabsorption; mathematical model; neostigmine; nutrition related tag; postoperative state; radionuclide diagnosis; radiotracer; technetium

The role of the ileo-colonic junction in modulating performance of the gastrointestinal tract has received little attention, though there is much to suggest that this junctional region has important functions. Thus, the capacity of the large bowel to respond normally, by converting chyme to formed stools, is influenced by the quality and quantity of luminal contents arriving in the proximal colon. The general hypothesis is that the distal ileium, ileocolonic sphincter (ICS) and proximal colon act together as a coordinated segment to regulate transit from ileum to colon; moreover, proper functioning of these mechanisms contributes significantly to normal performance of the distal bowel. Reasons for the relative lack of information on the ileocolonic junction include the inaccessability of the region. In the initial funding period of this grant, methods have been developed which allow the ileocolonic junction to be investigated in dog and man. Further methodological approaches are proposed here together with extensions of earlier studies which will address the mechanisms for control of motility and transit in the region. The experiments described here have the following Specific Aims: 1. To utilize an established and well-characterized canine model to evaluate control of ileocecal motility and transit. The roles of neuro-peptides and pharmacologic agents will be examined. 2. To refine methods by which ileocecal motility and transit can be quantified and correlated in man, and to further evaluate the control of ileocecal function in man. 3. To establish the role of disorders of ileocolonic motility in defined syndromes of gastrointestinal disease. The work outlined here should have direct application to the better understanding of several common gastrointestinal diseases; these include malabsorption syndromes, non-specific diarrhea, irritable bowel syndrome, and the postoperative physiology that follows gastrointestinal surgery.

回结肠连接在调节结肠性能中的作用 胃肠道虽然受到很多关注，但很少受到关注 表明这个交界区具有重要的功能。 因此， 大肠通过将食糜转化为正常反应的能力 粪便的形成，受管腔内的质量和数量的影响 内容物到达近端结肠。 一般假设是 远端回肠、回结肠括约肌 (ICS) 和近端结肠 作为一个协调的部分一起调节从回肠到结肠的运输； 此外，这些机制的正常运作也非常有助于 远端肠的正常表现。 回结肠交界处信息相对缺乏的原因 包括该地区的交通不便。 在初始资助期内 这笔赠款的方法已经开发出来，允许回结肠 狗和人的交界处需要调查。 进一步的方法论 这里提出的方法以及早期研究的扩展 这将涉及控制运动和过境的机制 该地区。 这里描述的实验有以下具体目标： 1. 利用已建立且特征良好的犬类模型 评估回盲部运动和运输的控制。 的角色 将检查神经肽和药物制剂。 2. 完善回盲部运动和运输的方法 在人类中进行量化和相关性，并进一步评估对 人类的回盲部功能。 3. 确定回结肠运动障碍在定义中的作用 胃肠道疾病综合症。 这里概述的工作应该直接应用于更好的 了解几种常见胃肠道疾病；这些包括 吸收不良综合征、非特异性腹泻、肠易激综合征、 以及胃肠道手术后的术后生理学。