HDHL-Biomarkers: Early life programming of childhood health: a nutritional and epigenetic investigation (ALPHABET)

HDHL-生物标记：儿童健康的早期生命规划：营养和表观遗传学研究 (ALPHABET)

• 批准号: BB/P028187/1
• 负责人: Caroline Relton
• 金额: $ 12.9万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP028187%2F1
• 关键词: HDHL; Biomarkers; Early; life; programming

The rising prevalence of obesity, cardiometabolic disease, asthma, osteoporosis and neurodevelopmental disorders over recent decades cannot be fully explained by genetic or adult lifestyle factors. Increasing evidence suggests links to early life environmental factors. If such links exist, then there must be non-genetic mechanisms that retain memory of early life exposures such as suboptimal nutrition during pregnancy or early childhood and that influence health decades later. DNA methylation, the addition of methyl groups to DNA, has been proposed as a possible mechanism because it is responsive to the environment and influences gene expression. Maternal diet during pregnancy is a modifiable behaviour that could impact on maternal, neonatal and child health. However the specific dietary requirements during pregnancy for optimal fetal growth and development are unknown in large part because effects on health only begin to appear decades after exposure. DNA methylation patterns however should be affected almost immediately and, if they are linked to later health outcomes, should remain throughout life. This project will utilise biological samples and data from existing European longitudinal birth cohorts to investigate the complex relationships between maternal diet summarised by indices of diet quality and inflammatory potential, health outcomes and DNA methylation patterns from birth throughout childhood and into adulthood. Hence, we will be able to observe how prenatal diet modifies infant DNA methylation patterns and if and how these modifications are maintained throughout life and relate to health outcomes in adulthood. These observations may aid development of more refined dietary recommendations for promoting optimal health throughout life.

近几十年来，肥胖症、心脏代谢疾病、哮喘、骨质疏松症和神经发育障碍的发病率不断上升，不能完全用遗传或成人生活方式因素来解释。越来越多的证据表明与早期生活环境因素有关。如果存在这种联系，那么一定存在非遗传机制，保留了对早期生活暴露的记忆，如怀孕或幼儿期的次优营养，并影响几十年后的健康。DNA甲基化，甲基基团添加到DNA，已被提出作为一种可能的机制，因为它是响应于环境和影响基因表达。孕妇在怀孕期间的饮食是一种可以改变的行为，可能会影响产妇、新生儿和儿童的健康。然而，在怀孕期间为使胎儿生长和发育达到最佳状态所需的具体饮食要求在很大程度上是未知的，因为对健康的影响只有在接触后几十年才开始出现。然而，DNA甲基化模式应该几乎立即受到影响，如果它们与以后的健康结果有关，应该在整个生命中保持。该项目将利用来自现有欧洲纵向出生队列的生物样本和数据，调查母亲饮食（通过饮食质量和炎症潜力指数总结）、健康结果和DNA甲基化模式之间的复杂关系。因此，我们将能够观察产前饮食如何改变婴儿DNA甲基化模式，以及这些修饰是否以及如何在整个生命中保持并与成年后的健康结果相关。这些观察结果可能有助于制定更完善的饮食建议，以促进一生的最佳健康。

项目成果

The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis

妊娠期补充维生素 D 对后代儿童期骨矿物质密度的影响：系统评价和荟萃分析

• DOI: 10.1007/s00198-023-06751-5
• 发表时间: 2023
• 期刊: Osteoporosis International
• 影响因子: 4
• 作者: Moon R

Associations of maternal dietary inflammatory potential and quality with offspring birth outcomes: An individual participant data pooled analysis of 7 European cohorts in the ALPHABET consortium.

• DOI: 10.1371/journal.pmed.1003491
• 发表时间: 2021-01
• 期刊: PLoS medicine
• 影响因子: 15.8
• 作者: Chen LW;Aubert AM;Shivappa N;Bernard JY;Mensink-Bout SM;Geraghty AA;Mehegan J;Suderman M;Polanska K;Hanke W;Trafalska E;Relton CL;Crozier SR;Harvey NC;Cooper C;Duijts L;Heude B;Hébert JR;McAuliffe FM;Kelleher CC;Phillips CM
• 通讯作者: Phillips CM

Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium.

• DOI: 10.1186/s12916-021-01908-7
• 发表时间: 2021-02-22
• 期刊: BMC medicine
• 影响因子: 9.3
• 作者: Chen LW;Aubert AM;Shivappa N;Bernard JY;Mensink-Bout SM;Geraghty AA;Mehegan J;Suderman M;Polanska K;Hanke W;Jankowska A;Relton CL;Crozier SR;Harvey NC;Cooper C;Hanson M;Godfrey KM;Gaillard R;Duijts L;Heude B;Hébert JR;McAuliffe FM;Kelleher CC;Phillips CM
• 通讯作者: Phillips CM

Early-life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

• DOI: 10.1111/nbu.12322
• 发表时间: 2018-06-01
• 期刊: NUTRITION BULLETIN
• 影响因子: 3.3
• 作者: Curtis, E. M.;Suderman, M.;Harvey, N. C.
• 通讯作者: Harvey, N. C.