Epigenetic Epidemiology

表观遗传流行病学

• 批准号: MC_UU_00011/5
• 负责人: Caroline Relton
• 金额: $ 159.78万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00011%2F5
• 关键词: Epigenetic; Epidemiology

This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.

该计划旨在通过使用流行病学方法更好地了解表观遗传变异的决定因素和后果。我们将通过大规模GWAS分析扩展我们对基因组中常见遗传变异和DNA甲基化之间关系的了解。识别标记甲基化变异的遗传变异将增强我们进行孟德尔随机化以加强因果推断的能力。我们将开发DNA甲基化作为疾病预测和预后的生物标志物以及暴露于疾病风险因素的指数的用途。最后，我们将结合联合收割机的这些元素的程序和其他方法的进步，在表观遗传流行病学，以解决各种疾病的具体研究问题。

项目成果

DNA methylation derived systemic inflammation indices are associated with head and neck cancer development and survival.

• DOI: 10.1016/j.oraloncology.2018.08.021
• 发表时间: 2018-10
• 期刊: Oral oncology
• 影响因子: 4.8
• 作者: Ambatipudi S;Langdon R;Richmond RC;Suderman M;Koestler DC;Kelsey KT;Kazmi N;Penfold C;Ho KM;McArdle W;Ring SM;Pring M;Waterboer T;Pawlita M;Gaunt TR;Davey Smith G;Thomas S;Ness AR;Relton CL
• 通讯作者: Relton CL

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study.

• DOI: 10.1158/1055-9965.epi-18-0079
• 发表时间: 2019-01
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Adams CD;Richmond R;Ferreira DLS;Spiller W;Tan V;Zheng J;Würtz P;Donovan J;Hamdy F;Neal D;Lane JA;Smith GD;Relton C;Eeles RA;Haiman CA;Kote-Jarai Z;Schumacher FR;Olama AAA;Benlloch S;Muir K;Berndt SI;Conti DV;Wiklund F;Chanock SJ;Gapstur S;Stevens VL;Tangen CM;Batra J;Clements JA;Gronberg H;Pashayan N;Schleutker J;Albanes D;Wolk A;West CML;Mucci LA;Cancel-Tassin G;Koutros S;Sorensen KD;Maehle L;Travis RC;Hamilton RJ;Ingles SA;Rosenstein BS;Lu YJ;Giles GG;Kibel AS;Vega A;Kogevinas M;Penney KL;Park JY;Stanford JL;Cybulski C;Nordestgaard BG;Brenner H;Maier C;Kim J;John EM;Teixeira MR;Neuhausen SL;De Ruyck K;Razack A;Newcomb LF;Lessel D;Kaneva RP;Usmani N;Claessens F;Townsend PA;Dominguez MG;Roobol MJ;Menegaux F;Khaw KT;Cannon-Albright LA;Pandha H;Thibodeau SN;Martin RM;PRACTICAL consortium
• 通讯作者: PRACTICAL consortium

Protecting against researcher bias in secondary data analysis: challenges and potential solutions.

• DOI: 10.1007/s10654-021-00839-0
• 发表时间: 2022-01
• 期刊: European journal of epidemiology
• 影响因子: 13.6
• 作者: Baldwin JR;Pingault JB;Schoeler T;Sallis HM;Munafò MR
• 通讯作者: Munafò MR

Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.

• DOI: 10.1155/2018/2624981
• 发表时间: 2018
• 期刊: Journal of immunology research
• 影响因子: 4.1
• 作者: Ambatipudi S;Sharp GC;Clarke SLN;Plant D;Tobias JH;Evans DM;Barton A;Relton CL
• 通讯作者: Relton CL