Epigenetic Epidemiology

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This programme aims to gain a better understanding of the determinants and consequences of epigenetic variation through the use of epidemiological approaches. We will extend our knowledge of the relationship between common genetic variation and DNA methylation across the genome through large scale GWAS analysis. The identification of genetic variants that tag methylation variation will enhance our ability to conduct Mendelian randomization to strengthen causal inference. We will develop our use of DNA methylation as a biomarker of disease prediction and prognosis as well as an index of exposure to disease risk factors. Lastly, we will combine these elements of the programme and other methodological advances in epigenetic epidemiology to address a variety of disease specific research questions.