PERIPHERAL AND CENTRAL SATIETY ACTIONS OF BOMBESIN

这项建议有三个主要目的： 首先，确定饱腹感的作用部位和传入途径 外源性蛙皮素在大鼠体内的作用； 几秒钟，以检验食物在人体内的饱腹感 至少在一定程度上，胃是通过从胃中释放的蛙皮素来调节的。 大鼠胃内； 第三，分析饱腹感的神经和/或内分泌机制 大鼠下丘脑外侧注射蛙皮素的作用。 主题是继续分析前吸收的作用 诱导的机制(尤其是多肽功能) 餐后饱腹感。中心目标是确定外围设备 控制食物大小的机制。这一知识应该呈现在 开发以生理为基础的肥胖症和 治疗暴食症。

This proposal has three major purposes: First, to determine the site of action and afferent pathway for the satiety action of exogenous bombesin administered perpherally in the rat; Seconds, to test the hypothesis that the satiating effect of food in the stomach is mediated, at least in part, by bombesin released from the stomach in the rat; Third, to analyze the neural and/or endocrine mechanisms of the satiety effect of lateral hypothalamic injections of bombesin in the rat. The theme is to continue the analysis of the role of preabsorptive mechanisms (especially peptide functions) in the elicitation of postprandial satiety. The central goal is to determine the peripheral mechanisms controlling meal size. This knowledge should present opportunities to develop physiologically-based treatments for obesity and for bulimia.