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How do Phototropin Receptor Kinases Initiate Signalling from the Plasma Membrane?

向光素受体激酶如何启动质膜信号传导？

基本信息

批准号：
BB/R001499/1
负责人：
John Christie
金额：
$ 58.18万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FR001499%2F1
关键词：
How do Phototropin Receptor Kinases

项目摘要

Improving crop yield has the potential to overcome the challenges facing global agriculture. Strategies to increase plant biomass have centred on enhancing photosynthetic productivity. Phototropin receptor kinases (phots) play an important role in this regard as they function to control a wide range of physiological responses that collectively serve to optimise photosynthetic efficiency. These include chloroplast relocation movements, leaf positioning and expansion, stomatal opening and phototropism, all of which influence a plant's photosynthetic competence by improving the efficiency of light capture, reducing photodamage, and regulating gas exchange between leaves and the atmosphere. Manipulating these processes could offers considerable potential to alter plant growth through changes in photosynthetic performance. Yet, despite two decades of research, our understanding of how these autophosphorylating kinases are activated, how they are regulated and how they initiate signalling from the plasma membrane is far from complete. Obtaining a better grasp of the underlying mechanisms involved will be essential if we are to harness the full potential of altering phot function for agronomic gain. This proposal will capitalise on a substantial body of preliminary work to answer key gaps in our knowledge regarding the molecular basis underlying phot receptor activation and signalling by light. The outcomes of this work will ultimately offer new opportunities to coordinate enhancements in photosynthetic performance with an aim to increase yield and grow crops more efficiently. Knowledge gained from this work will also translate to related kinases with key roles in controlling plant immunity and the hormonal regulation of plant development.

提高作物产量有可能克服全球农业面临的挑战。增加植物生物量的策略集中于提高光合作用生产力。向光素受体激酶（photos）在这方面发挥着重要作用，因为它们的功能是控制广泛的生理反应，这些反应共同优化光合作用效率。这些包括叶绿体重新定位运动、叶片定位和扩张、气孔开放和向光性，所有这些都通过提高光捕获效率、减少光损伤以及调节叶片与大气之间的气体交换来影响植物的光合作用能力。操纵这些过程可以提供通过改变光合作用性能来改变植物生长的巨大潜力。然而，尽管进行了二十年的研究，我们对这些自磷酸化激酶如何被激活、它们如何被调节以及它们如何从质膜启动信号传导的了解还远未完成。如果我们要充分利用改变光功能以获得农艺收益的潜力，那么更好地掌握所涉及的潜在机制至关重要。该提案将利用大量的前期工作来回答我们在光受体激活和光信号传导的分子基础方面的知识中的关键空白。这项工作的成果最终将为协调光合作用性能的增强提供新的机会，以提高产量并更有效地种植作物。从这项工作中获得的知识也将转化为在控制植物免疫和植物发育的激素调节中发挥关键作用的相关激酶。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

CIPK23 regulates blue light-dependent stomatal opening in Arabidopsis thaliana.

DOI：
10.1111/tpj.14955
发表时间：
2020-11
期刊：
The Plant journal : for cell and molecular biology
影响因子：
0
作者：
Inoue SI;Kaiserli E;Zhao X;Waksman T;Takemiya A;Okumura M;Takahashi H;Seki M;Shinozaki K;Endo Y;Sawasaki T;Kinoshita T;Zhang X;Christie JM;Shimazaki KI
通讯作者：
Shimazaki KI

Regulation of plant phototropic growth by NPH3/RPT2-like substrate phosphorylation and 14-3-3 binding.

DOI：
10.1038/s41467-021-26333-5
发表时间：
2021-10-21
期刊：
Nature communications
影响因子：
16.6
作者：
Sullivan S;Waksman T;Paliogianni D;Henderson L;Lütkemeyer M;Suetsugu N;Christie JM
通讯作者：
Christie JM

The fluorescent protein iLOV as a reporter for screening of high-yield production of antimicrobial peptides in Pichia pastoris.