Deciphering the tissue-specific role of the transcription factor SKN-1B in C. elegans to promote a long and healthy life.
破译转录因子 SKN-1B 在秀丽隐杆线虫中的组织特异性作用,以促进长寿和健康的生活。
基本信息
- 批准号:BB/R003629/1
- 负责人:
- 金额:$ 58.43万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With age, it is unfortunate that humans succumb to a variety of debilitating conditions e.g. brain degeneration, diabetes, heart problems and muscle degeneration to name but four. However, it is difficult to study ageing in humans due to the time scales involved. To circumvent this problem, scientists use simpler organisms such as worms, flies and mice. In particular, studies with a nematode worm (Latin name C. elegans) have been instrumental to discovering and understanding the ageing process. For example, it is possible to increase or decrease lifespan in worms by altering the activity of various molecules and amazingly, interventions that extend lifespan often also improve the age-related health of the animals. Thus, these studies have shown that it is possible not only to extend lifespan but also the quality of life. As most of the molecules identified in this research are also present in human cells, by studying their effects on lifespan in simple organisms, we will eventually be able to use this information to design approaches to slow ageing and improve the late-life health of humans.In worms, one important ageing molecule is called SKN-1. It is equivalent (in terms of its function) to the human Nrf proteins. If SKN-1 activity is decreased then worms have a shorter lifespan and, conversely if SKN-1 activity is increased so is their lifespan. Understanding how SKN-1 works is therefore key to understanding the ageing process and developing ways to intervene in it. SKN-1/Nrf has a very important role in cells because it allows them to respond to and survive stressful conditions. It is also very important for regulating protein homeostasis and metabolism. We want to understand how these and other functions are important for controlling ageing and as the SKN-1 molecules present in worms are similar to those in humans, our work has real relevance to a better understanding of human ageing.There is currently considerable interest in identifying genetic or chemical modulators to extend lifespan and thus improve lifelong health. We know that SKN-1 is important for these processes and, it is particularly interesting to study as it is already an established drug target. So, by defining how it works we will be able to harness this to develop anti-ageing therapies and therefore lay the foundations of knowledge that will be useful for promoting long and healthy human lives.
不幸的是,随着年龄的增长,人类会遭受各种使人衰弱的疾病,例如老年痴呆症。大脑退化、糖尿病、心脏问题和肌肉退化仅举四例。然而,由于涉及的时间尺度,研究人类的衰老很困难。为了解决这个问题,科学家们使用了更简单的生物体,如蠕虫、苍蝇和老鼠。特别是,对线虫(拉丁名线虫)的研究有助于发现和理解衰老过程。例如,通过改变各种分子的活性可以增加或减少蠕虫的寿命,令人惊讶的是,延长寿命的干预措施通常也可以改善动物与年龄相关的健康。因此,这些研究表明,不仅可以延长寿命,还可以提高生活质量。由于这项研究中发现的大多数分子也存在于人类细胞中,通过研究它们对简单生物体寿命的影响,我们最终将能够利用这些信息来设计减缓衰老和改善人类晚年健康的方法。在线虫中,一种重要的衰老分子被称为 SKN-1。它(就其功能而言)与人类 Nrf 蛋白相同。如果 SKN-1 活性降低,那么蠕虫的寿命就会缩短,相反,如果 SKN-1 活性增加,它们的寿命也会缩短。因此,了解 SKN-1 的工作原理是了解衰老过程和开发干预方法的关键。 SKN-1/Nrf 在细胞中发挥着非常重要的作用,因为它使细胞能够对应激条件做出反应并生存下来。它对于调节蛋白质稳态和代谢也非常重要。我们希望了解这些功能和其他功能对于控制衰老有何重要意义,并且由于蠕虫中存在的 SKN-1 分子与人类中的相似,因此我们的工作对于更好地了解人类衰老具有真正的相关性。目前,人们对识别遗传或化学调节剂以延长寿命并从而改善终生健康非常感兴趣。我们知道 SKN-1 对于这些过程很重要,并且研究特别有趣,因为它已经是一个既定的药物靶点。因此,通过定义它的工作原理,我们将能够利用它来开发抗衰老疗法,从而奠定有助于促进人类长寿和健康的知识基础。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging.
- DOI:10.1016/j.exger.2020.110919
- 发表时间:2020-07-01
- 期刊:
- 影响因子:3.9
- 作者:Spurlock B;Tullet J;Hartman JL 4th;Mitra K
- 通讯作者:Mitra K
Neuronal SKN-1B modulates nutritional signalling pathways and mitochondrial networks to control satiety.
- DOI:10.1371/journal.pgen.1009358
- 发表时间:2021-03
- 期刊:
- 影响因子:4.5
- 作者:Tataridas-Pallas N;Thompson MA;Howard A;Brown I;Ezcurra M;Wu Z;Silva IG;Saunter CD;Kuerten T;Weinkove D;Blackwell TK;Tullet JMA
- 通讯作者:Tullet JMA
Signal Transduction Pathways in Ageing.
衰老中的信号转导途径。
- DOI:10.1007/978-981-13-2835-0_11
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Slack C
- 通讯作者:Slack C
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Jennifer Tullet其他文献
Jennifer Tullet的其他文献
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{{ truncateString('Jennifer Tullet', 18)}}的其他基金
How food speaks to you: A new brain-gut axis for lifelong health.
食物如何与你对话:终身健康的新脑肠轴。
- 批准号:
BB/X014584/1 - 财政年份:2023
- 资助金额:
$ 58.43万 - 项目类别:
Research Grant
RNA Polymerase III in healthy ageing: Consolidating the mechanisms of longevity from worms and flies to mice
RNA聚合酶III在健康衰老中的作用:巩固从蠕虫和苍蝇到小鼠的长寿机制
- 批准号:
BB/S014365/1 - 财政年份:2019
- 资助金额:
$ 58.43万 - 项目类别:
Research Grant
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