Pathways to neo-functionalization: the past and future of strigolactone signalling

新功能化途径：独脚金内酯信号传导的过去和未来

• 批准号: BB/R00398X/1
• 负责人: Thomas Bennett
• 金额: $ 53.38万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR00398X%2F1
• 关键词: Pathways; neo; functionalization; past; future

Hormonal signalling pathways are vitally important in the regulation of plant growth and development. Strigolactones (SLs) and 'KAI2-Ligand' (KL) are closely related hormonal signals that regulate specific aspects of development, including shoot branching and seed germination. In flowering plants, including most crop plants, SL and KL act through very closely related signalling pathways to regulate development. In evolutionary terms, SL signalling appears to have arisen by duplication of the KL signalling pathway. Indeed, in non-flowering plants, there is evidence that the SL and KL signalling pathways overlap at least partially. This raises very intriguing questions as to whether the signalling pathways in flowering plants are truly separate, or whether they partially or even fully overlap.This project aims to assess to what extent the SL and KL signalling pathways in flowering plants are separated from each other, and to understand at a molecular level how this 'specificity' arises. The main hypothesis we will test is that the perception of SL and KL by receptor proteins is highly specific, but that the mechanisms by which these pathways regulate development are very similar and at least partially overlapping. To address this question, the project will bring together a wealth newly available genomic data, with a powerful experimental system in the model plant Arabidopsis thaliana. By assessing how SL and KL signalling have evolved throughout the 500 million year history of land plants, we can formulate hypotheses regarding the specificity of these pathways, which we can then test in the context of Arabidopsis lateral root development. This project will allow us to understand how plants could be bred to enhance or diminish certain effects of SL or KL in order to improve yields. In summary, by analysing the past and present of SL and KL signalling, we can define possibilities for future crop improvement.

激素信号通路在植物生长发育的调控中起着至关重要的作用。独脚金内酯（SL）和“KAI 2-配体”（KL）是密切相关的激素信号，其调节发育的特定方面，包括芽分枝和种子萌发。在开花植物中，包括大多数作物植物，SL和KL通过非常密切相关的信号通路来调节发育。在进化方面，SL信号似乎已经出现了KL信号通路的复制。事实上，在非开花植物中，有证据表明SL和KL信号通路至少部分重叠。这就提出了一个非常有趣的问题，即显花植物中的信号通路是否真的是独立的，或者它们是否部分甚至完全重叠。本项目旨在评估显花植物中SL和KL信号通路在多大程度上相互分离，并在分子水平上了解这种“特异性”是如何产生的。我们将检验的主要假设是，SL和KL的受体蛋白的感知是高度特异性的，但这些途径调节发育的机制非常相似，至少部分重叠。为了解决这个问题，该项目将汇集大量新获得的基因组数据，并在模式植物拟南芥中建立一个强大的实验系统。通过评估SL和KL信号如何在陆地植物的5亿年历史中演变，我们可以制定关于这些途径特异性的假设，然后我们可以在拟南芥侧根发育的背景下进行测试。该项目将使我们了解如何培育植物以增强或减少SL或KL的某些影响，以提高产量。总之，通过分析SL和KL信号的过去和现在，我们可以定义未来作物改良的可能性。

项目成果

KAI2 regulates seedling development by mediating light-induced remodelling of auxin transport.

• DOI: 10.1111/nph.18110
• 发表时间: 2022-07
• 期刊: NEW PHYTOLOGIST
• 影响因子: 9.4
• 作者: Hamon-Josse, Maxime;Villaecija-Aguilar, Jose Antonio;Ljung, Karin;Leyser, Ottoline;Gutjahr, Caroline;Bennett, Tom
• 通讯作者: Bennett, Tom

KAI2 regulates root and root hair development by modulating auxin distribution

• DOI: 10.1101/539734
• 发表时间: 2019-02
• 期刊: bioRxiv
• 作者: J. Villaécija-Aguilar;Maxime Hamon-Josse;Samy Carbonnel;A. Kretschmar;K. Ljung;Tom Bennett;C. Gutjahr

Asymmetric expansions of FT and TFL1 lineages characterize differential evolution of the EuPEBP family in the major angiosperm lineages.

• DOI: 10.1186/s12915-021-01128-8
• 发表时间: 2021-08-31
• 期刊: BMC biology
• 影响因子: 5.4
• 作者: Bennett T;Dixon LE
• 通讯作者: Dixon LE

KAI2 promotes Arabidopsis root hair elongation at low external phosphate by controlling local accumulation of AUX1 and PIN2.

KAI2 通过控制 AUX1 和 PIN2 的局部积累，在低外部磷酸盐条件下促进拟南芥根毛伸长。

• DOI: 10.1016/j.cub.2021.10.044
• 发表时间: 2022
• 期刊: CB
• 作者: Villaécija-Aguilar JA

KAI2 regulates seedling development by mediating light-induced remodelling of auxin transport

KAI2 通过介导光诱导的生长素运输重塑来调节幼苗发育

• DOI: 10.1101/2021.05.06.443001
• 发表时间: 2021
• 作者: Hamon-Josse M