The Role of Dietary D-serine in Health and Disease

膳食 D-丝氨酸在健康和疾病中的作用

• 批准号: BB/R006539/1
• 负责人: Andrew Roe
• 金额: $ 75.47万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FR006539%2F1
• 关键词: Role; Dietary; serine; Health; Disease

The importance of our diet on health is well established yet hard to properly assess. Many so called "health foods", "super foods" and "probiotics" make bold claims but rigorously evaluating their effects is challenging, especially for complex systems like humans and other animals. If we can understand how specific components of our diet affect our chances of being infected by food poisoning bugs then we can make good dietary decisions or tailor our food to provide an inherent resistance to infection. The aim of our work is to understand how a specific D-amino acid (D-AA) affects susceptibility to, and recovery from, gastrointestinal infections. Wheres L-amino acids are the building blocks of proteins, D-amino acids can't be used in the same way so have largely been ignored by scientists. However, our work has shown that they play an important role in controlling the key weapons used by food poisoning bacteria. These D-amino acids are present is many processed food so it is now appropriate to look at how they affect our gut bacteria and how they affect gut pathogens.We have exciting new results showing that one specific D-amino acid can help restore the balance of the normal gut bacteria following infection. We propose to investigate the mechanism underlying this result using a mouse model that allows us to test the interplay between the host diet, gut bacteria and host defences in the resistance to pathogens. The work is important because we believe it will lead to new dietary-based strategies to combat a range of gastrointestinal infections, both acute and chronic.

我们的饮食对健康的重要性是公认的，但很难正确评估。许多所谓的“健康食品”、“超级食品”和“益生菌”都提出了大胆的主张，但严格评估它们的效果是具有挑战性的，特别是对于人类和其他动物这样的复杂系统。如果我们能够了解我们饮食中的特定成分如何影响我们被食物中毒病菌感染的机会，那么我们就可以做出良好的饮食决定，或者调整我们的食物，以提供对感染的内在抵抗力。我们工作的目的是了解特定的D-氨基酸（D-AA）如何影响胃肠道感染的易感性和恢复。L-氨基酸是蛋白质的组成部分，D-氨基酸不能以同样的方式使用，因此在很大程度上被科学家忽视了。然而，我们的工作表明，它们在控制食物中毒细菌使用的关键武器方面发挥着重要作用。这些D-氨基酸存在于许多加工食品中，因此现在应该看看它们如何影响我们的肠道细菌以及它们如何影响肠道病原体。我们有令人兴奋的新结果表明，一种特定的D-氨基酸可以帮助恢复感染后正常肠道细菌的平衡。我们建议使用小鼠模型来研究这一结果的机制，该模型使我们能够测试宿主饮食，肠道细菌和宿主防御之间的相互作用，以抵抗病原体。这项工作很重要，因为我们相信它将导致新的基于饮食的策略，以对抗一系列急性和慢性胃肠道感染。

项目成果

Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

• DOI: 10.1038/s41467-018-06701-4
• 发表时间: 2018-10-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Connolly JPR;Slater SL;O'Boyle N;Goldstone RJ;Crepin VF;Ruano-Gallego D;Herzyk P;Smith DGE;Douce GR;Frankel G;Roe AJ
• 通讯作者: Roe AJ

Author Correction: Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion.

• DOI: 10.1038/s41467-018-07612-0
• 发表时间: 2018-11-29
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Connolly JPR;Slater SL;O'Boyle N;Goldstone RJ;Crepin VF;Ruano-Gallego D;Herzyk P;Smith DGE;Douce GR;Frankel G;Roe AJ
• 通讯作者: Roe AJ

Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associated Escherichia coli.

• DOI: 10.1073/pnas.2210299119
• 发表时间: 2022-11-08
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity.

• DOI: 10.1007/s00394-019-02161-8
• 发表时间: 2020-10
• 期刊: European journal of nutrition
• 影响因子: 5
• 作者: Gerasimidis K;Bryden K;Chen X;Papachristou E;Verney A;Roig M;Hansen R;Nichols B;Papadopoulou R;Parrett A
• 通讯作者: Parrett A

D-serine induces distinct transcriptomes in diverse Escherichia coli pathotypes

D-丝氨酸在不同的大肠杆菌致病型中诱导不同的转录组

• DOI: 10.1101/2021.05.12.443952
• 发表时间: 2021
• 作者: Connolly J