OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS

我们建议继续研究臭氧的基本有机化学 以及这种化学与环境健康的关系， 特别强调诱变和致癌作用。 我们会进行碳氧化合物和二环氧乙烷的物理有机研究 为了确定电子，空间和立体化学 这两类有机物的溶液反应的要求 过氧化物 我们还将进行单独的气相羰基反应， 具有代表性的多环芳烃的氧化物和二环氧乙烷 其已被模型颗粒材料吸收。 的产品 这些反应将通过TLC、GPC和HPLC方法分离，然后 鉴定 在二环氧乙烷的情况下，它是黄色的，因此 由于在环境大气条件下会发生光解， 还将在溶液和气体中进行光化学研究 相位 需要二环氧乙烷的反应将利用新的 发现了一种技术，可以制备纯的 二环氧乙烷。 这些综合研究将使我们能够评估单独的潜力， 空气中的多环芳烃被羰基氧化物、二环氧乙烷和臭氧活化。 这一评估反过来又与可能的大气层形成有关， 致突变物/致癌物这三种化学试剂。

We propose to continue our studies on the basic organic chemistry of ozone and the relationship of that chemistry to environmental health with particular emphasis on mutagenesis and carcinogenesis. We will conduct physical organic studies on carbonyl oxides and dioxiranes in order to determine the electronic, steric, and stereochemical requirements for solution reactions of these two classes of organic peroxides. We will also carry out separate gas phase reactions of carbonyl oxides and dioxiranes with representative polycyclic aromatic hydrocarbons which have been absorbed on model particulate materials. The products of these reactions will be isolated by TLC, GPC and HPLC methods and then identified. In the case of dioxiranes, which are yellow-colored and hence subject to photolysis under ambient atmospheric conditions, some photochemical studies will also be carried out both in solution and the gas phase. The reactions requiring dioxiranes will take advantage of a newly discovered technique which permits preparation of solutions of pure dioxiranes. These combined studies will permit us to assess the separate potential for atmosphere activation of PAH by carbonyl oxides, dioxiranes, and ozone. This assessment in turn is related to the possible atmospheric formation of mutagens/carcinogens by these three chemical agents.