OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS

我们建议继续研究臭氧的基本有机化学。 以及这种化学物质与环境健康的关系 特别强调诱变和致癌。 我们的具体目标包括学习基础臭氧化学和化学 臭氧衍生的氧化剂、羰基氧化物和二氧六环。多环芳烃 被模型颗粒吸收的颗粒物将暴露在含有以下物质的气流中： 1)臭氧和2)臭氧-烯烃反应混合物。产品差异 这两种类型的反应的分布将指示反应 在多环芳烃和臭氧衍生的氧化剂之间。芳烃氧化物的存在 在臭氧-烯烃实验中可能与产生 污染大气中的致突变物/致癌物。这个世界的本质 将确定负责任的氧化剂(环氧乙烷或环氧乙烷)。 不同温度下四取代烯烃溶液的臭氧化反应 将研究浓度以寻找二氧环己烷形成的证据。 将寻求合成二氧六环的改进方法。这个 二氧六环与饱和烃的反应将在 反应条件多种多样。溶剂对环氧化反应速率的影响 由二氧六环将被测量。

We propose to continue our studies on the basic organic chemistry of ozone and the relationship of that chemistry to environmental health with particular emphasis on mutagenesis and carcinogenesis. Our specific aims include studying basic ozone chemistry and the chemistry of the ozone-derived oxidants, carbonyl oxides and dioxiranes. PAH's absorbed on model particulates will be exposed to a gas stream containing: 1) ozone and 2) an ozone-alkene reaction mixture. Differences in product distributions in these two types of reactions will indicate reactions between the PAH's and ozone-derived oxidants. The presence of arene oxides in the ozone-alkene experiments could be related to the production of mutagens/carcinogens in polluted atmospheres. The nature of the responsible oxidant (carbonyl oxide or dioxirane) will be determined. Ozonolysis of solutions of tetra-substituted alkenes at varying concentration will be studied for evidence of dioxirane formation. Improved methods for the synthesis of dioxiranes will be sought. The reactions of dioxiranes with saturated hydrocarbons will be studied under a variety of reaction conditions. Solvent effects on the rate of epoxidation by dioxiranes will be measured.