OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS

我们建议继续研究臭氧的基本有机化学。 以及这种化学物质与环境健康的关系 特别强调诱变和致癌。 我们将对羰基氧化物和二氧六环进行物理有机研究。 为了确定电子的、立体的和立体化学的 这两类有机化合物的溶液反应要求 过氧物。我们还将进行单独的气相羰基反应。 具有代表性多环芳烃的氧化物和二氧六环 它们已经被模型颗粒材料吸收了。的产品 这些反应将通过TLC，GPC和HPL C方法分离，然后 已确认身份。在二氧六环的情况下，它是黄色的，因此 在环境大气条件下会发生光解，有些 还将在溶液和气体中进行光化学研究。 相位。 需要二氧六环的反应将利用一个新的 发现了一种技术，允许制备纯净的溶液 二氧六环。 这些综合研究将使我们能够评估 大气中多环芳烃被羰基氧化物、二氧六环和臭氧活化。 这一评估反过来又与可能的大气形成有关 这三种化学物质所致的诱变剂/致癌物。

We propose to continue our studies on the basic organic chemistry of ozone and the relationship of that chemistry to environmental health with particular emphasis on mutagenesis and carcinogenesis. We will conduct physical organic studies on carbonyl oxides and dioxiranes in order to determine the electronic, steric, and stereochemical requirements for solution reactions of these two classes of organic peroxides. We will also carry out separate gas phase reactions of carbonyl oxides and dioxiranes with representative polycyclic aromatic hydrocarbons which have been absorbed on model particulate materials. The products of these reactions will be isolated by TLC, GPC and HPLC methods and then identified. In the case of dioxiranes, which are yellow-colored and hence subject to photolysis under ambient atmospheric conditions, some photochemical studies will also be carried out both in solution and the gas phase. The reactions requiring dioxiranes will take advantage of a newly discovered technique which permits preparation of solutions of pure dioxiranes. These combined studies will permit us to assess the separate potential for atmosphere activation of PAH by carbonyl oxides, dioxiranes, and ozone. This assessment in turn is related to the possible atmospheric formation of mutagens/carcinogens by these three chemical agents.