China/UK/Thailand Program on Poultry Biosafety for Salmonella, E. coli and Campylobacter (CUT-SEC)
中国/英国/泰国家禽沙门氏菌、大肠杆菌和弯曲杆菌生物安全项目 (CUT-SEC)
基本信息
- 批准号:BB/R012776/1
- 负责人:
- 金额:$ 197.82万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The world's population is increasing, particularly in low-middle income countries and by 2050 as a global community we will have to feed an additional 2 billion people. This population explosion will place greater emphasis on meat production, particularly poultry. It is estimated by the world bank that by 2030, China, India and SE Asia will supply 80% of the world meat trade which will include national consumption and international export. The question is - how will this be met? Poultry farming will need to intensify to meet these global needs with the inevitable increase in antibiotic consumption used in animal feeds despite reservations from world authorities (WHO, FAO etc.). The AMR prevalence in chicken is considerably higher than other animal sectors due to the use of uncontrolled animal feeds and the potential for cross-contamination, either during growth or at slaughter. We use antibiotics to fatten and increase poultry growth yield yet this too in causing serious antibiotic resistance in human pathogens. Antimicrobial resistance (AMR) is now deemed to be the biggest global threat facing humanity in the 21C. AMR has taken center stage as a global health issue yet most non-specialists are unaware the impact AMR will have on global populations and the potential it has of taking the treatment of infections back to the "dark ages". Hitherto, most studies around the world studying the impact of AMR have been small, one dimensional and often biased - too focused on AMR bacteria as oppose to studying the whole bacterial population. To understand the impact of AMR in the poultry sector we have established a network in Nth Thailand and mid-Eastern China (Shandong) and will undertake a comprehensive sampling strategy to examine key human food pathogens (Campylobacter, Salmonella and E. coli) in farms, the environment (water, flies, wild-birds) and community (human normal flora) and infections (urinary tract infections and gastroenteritis). Our Study (called CUT-SEC) has a comprehensive sampling platform: work package (WP) 1, chicken and duck sampling from hatcheries to slaughter; WP2, flies and wild birds; WP3, water samples and seepage; WP4, domestic animals on or near farms; WP5 Normal human rectal flora; WP6 community infections. We will analyze at least 70 samples every 3 months to examine seasonal variation and sample from Nth Thailand and Shandong. Bacteria will be analyzed by basic microbiology techniques and selected to be whole genome sequenced where we can interrogate the bacteria's whole DNA and compare it to other bacteria to see if they have spread from one sector (e.g. flies) to another (e.g. humans). This study will also sequence all the bacteria in the human gut to understand the dynamics of AMR bacterial populations. We will also undertake controlled experiments in chicken farms to monitor the spread on SEC and use mathematical models to understand how AMR pathogens spread in animals and their impact on human infections. The impact of this CUT-SEC will have immense consequences for the animal, human and economic sectors in Thailand and China. Our network is well established, has a proven track record of working together in Thailand and China and expertise to undertake this exciting and challenging proposal.
世界人口正在增加,特别是在中低收入国家,到2050年,作为一个全球社会,我们将不得不养活另外20亿人。这种人口爆炸将更加重视肉类生产,特别是家禽。据世界银行估计,到2030年,中国、印度和东南亚将供应世界肉类贸易的80%,包括国内消费和国际出口。问题是-如何实现这一目标?尽管世界权威机构(世卫组织、粮农组织等)有所保留,但随着动物饲料中抗生素消费量的不可避免的增加,家禽养殖业将需要加强以满足这些全球需求。由于使用不受控制的动物饲料以及在生长期间或屠宰时交叉污染的可能性,鸡肉中的AMR流行率远远高于其他动物部门。我们使用抗生素来催肥和增加家禽的生长产量,但这也导致了人类病原体对抗生素的严重耐药性。抗菌素耐药性(AMR)被认为是21世纪人类面临的最大全球威胁。AMR已成为全球健康问题的中心,但大多数非专业人士并不知道AMR将对全球人口产生的影响,以及它将感染治疗带回“黑暗时代”的潜力。目前,世界上大多数研究AMR影响的研究都是小规模的,一维的,而且往往有偏见-过于关注AMR细菌,而不是研究整个细菌种群。为了了解抗生素耐药性对家禽业的影响,我们在泰国北部和中国中东部(山东)建立了一个网络,并将采取全面的抽样策略,检查主要的人类食品病原体(弯曲杆菌、沙门氏菌和大肠杆菌)。大肠杆菌)、环境(水、苍蝇、野鸟)和社区(人类正常植物群)以及感染(尿路感染和胃肠炎)。我们的研究(称为CUT-SEC)有一个全面的采样平台:工作包(WP)1,从孵化场到屠宰场的鸡鸭采样; WP 2,苍蝇和野鸟; WP 3,水样和渗出液; WP 4,农场或附近的家畜; WP 5正常人直肠植物群; WP 6社区感染。我们将每3个月分析至少70个样本,以检查季节性变化,并从泰国北部和山东取样。细菌将通过基本的微生物学技术进行分析,并选择进行全基因组测序,我们可以询问细菌的整个DNA,并将其与其他细菌进行比较,以查看它们是否从一个部门(例如苍蝇)传播到另一个部门(例如人类)。这项研究还将对人类肠道中的所有细菌进行测序,以了解AMR细菌种群的动态。我们还将在养鸡场进行对照实验,以监测SEC的传播,并使用数学模型来了解AMR病原体如何在动物中传播及其对人类感染的影响。CUT-SEC的影响将对泰国和中国的动物、人类和经济部门产生巨大影响。我们的网络已经建立,在泰国和中国有着良好的合作记录,并拥有专业知识来承担这个令人兴奋和具有挑战性的提案。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pyrazolones Potentiate Colistin Activity against MCR-1-Producing Resistant Bacteria: Computational and Microbiological Study.
- DOI:10.1021/acsomega.2c07165
- 发表时间:2023-03-07
- 期刊:
- 影响因子:4.1
- 作者:Hanpaibool, Chonnikan;Ngamwongsatit, Natharin;Ounjai, Puey;Yotphan, Sirilata;Wolschann, Peter;Mulholland, Adrian J.;Spencer, James;Rungrotmongkol, Thanyada
- 通讯作者:Rungrotmongkol, Thanyada
Strain and lineage-level methylome heterogeneity in the multi-drug resistant pathogenic Escherichia coli ST101 clone
多重耐药致病性大肠杆菌 ST101 克隆的菌株和谱系水平甲基化组异质性
- DOI:10.1101/2020.06.07.138552
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Ashcroft M
- 通讯作者:Ashcroft M
An Emerging Clone, Klebsiellapneumoniae Carbapenemase 2-Producing K. pneumoniae Sequence Type 16, Associated With High Mortality Rates in a CC258-Endemic Setting.
- DOI:10.1093/cid/ciz1095
- 发表时间:2020-10-23
- 期刊:
- 影响因子:0
- 作者:Andrey DO;Pereira Dantas P;Martins WBS;Marques De Carvalho F;Almeida LGP;Sands K;Portal E;Sauser J;Cayô R;Nicolas MF;Vasconcelos ATR;Medeiros EA;Walsh TR;Gales AC
- 通讯作者:Gales AC
Antibiotic resistance, stewardship, and consumption - Authors' reply.
抗生素耐药性、管理和消费——作者的回复。
- DOI:10.1016/s2542-5196(18)30263-8
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Collignon P
- 通讯作者:Collignon P
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis.
- DOI:10.1016/s0140-6736(21)02724-0
- 发表时间:2022-02-12
- 期刊:
- 影响因子:0
- 作者:Antimicrobial Resistance Collaborators
- 通讯作者:Antimicrobial Resistance Collaborators
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Timothy Walsh其他文献
Assessing decision boundaries under uncertainty
评估不确定性下的决策边界
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:3.9
- 作者:
Wilkins Aquino;Jacob Desmond;Michael Eldred;Andrew Kurzawski;Cameron McCormick;Clay Sanders;Chandler Smith;Timothy Walsh - 通讯作者:
Timothy Walsh
Neural and Behavioral Mechanisms of Food Decision Making Across a Spectrum of Restrictive Eating
- DOI:
10.1016/j.biopsych.2020.02.078 - 发表时间:
2020-05-01 - 期刊:
- 影响因子:
- 作者:
Karin Foerde;Janet Schebendach;Nathaniel Daw;Timothy Walsh;Daphna Shohamy;Joanna Steinglass - 通讯作者:
Joanna Steinglass
Neocortical neuronal morphology in the Siberian Tiger (Panthera tigris altaica) and the clouded leopard (Neofelis nebulosa)
西伯利亚虎(Panthera tigris altaica)和云豹(Neofelis nebulosa)的新皮质神经元形态
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
Cameron B. Johnson;M. Schall;Mackenzie E. Tennison;Madeleine E Garcia;N. B. Shea;M. Raghanti;A. Lewandowski;Mads F Bertelsen;Leona C. Waller;Timothy Walsh;John F. Roberts;P. Hof;C. Sherwood;P. Manger;B. Jacobs - 通讯作者:
B. Jacobs
The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers
美罗培南、阿维巴坦和金属-β-内酰胺酶抑制剂的三重组合可优化针对不同 β-内酰胺酶生产者的抗菌覆盖范围
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:12.8
- 作者:
Zhuoren Ling;Alistair James Macdonald Farley;Aditya Lankapalli;Yanfang Zhang;Shonnette Premchand;Kate Cook;Andrei Baran;Charlotte Gray;Claudia Orbegozo Rubio;Edgars Suna;Jordan Mathias;J. Brem;Kirsty Sands;Maria Nieto;Maria Mykolaivna Trush;Nadira Naznin Rakhi;Willames Martins;Yuqing Zhou;Christopher Joseph Schofield;Timothy Walsh - 通讯作者:
Timothy Walsh
Process Improvement: Use of UV-C for Healthcare Cell Phone Disinfection.
工艺改进:使用 UV-C 进行医疗保健手机消毒。
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:4.9
- 作者:
Jacqueline Christie;Timothy Walsh;Christopher Lee;P. Stefanacci - 通讯作者:
P. Stefanacci
Timothy Walsh的其他文献
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{{ truncateString('Timothy Walsh', 18)}}的其他基金
The disulfide bond as a chemical tool in cyclic peptide antibiotics: engineering disulfide polymyxins and murepavadin
二硫键作为环肽抗生素的化学工具:工程化二硫多粘菌素和 murepavadin
- 批准号:
MR/Y033809/1 - 财政年份:2024
- 资助金额:
$ 197.82万 - 项目类别:
Research Grant
Determining the clinical and environmental impact, burden and cost of Extensively Drug Resistant Enterobacteriaceae in China (DETER-XDRE-CHINA-HUB)
确定中国广泛耐药肠杆菌科细菌的临床和环境影响、负担和成本 (DETER-XDRE-CHINA-HUB)
- 批准号:
MR/S013768/2 - 财政年份:2020
- 资助金额:
$ 197.82万 - 项目类别:
Research Grant
Determining the clinical and environmental impact, burden and cost of Extensively Drug Resistant Enterobacteriaceae in China (DETER-XDRE-CHINA-HUB)
确定中国广泛耐药肠杆菌科细菌的临床和环境影响、负担和成本 (DETER-XDRE-CHINA-HUB)
- 批准号:
MR/S013768/1 - 财政年份:2019
- 资助金额:
$ 197.82万 - 项目类别:
Research Grant
Determining the clinical and environmental impact, burden and cost of extensively drug resistant Enterobacteriaceae in China (DETER-XDRE-CHINA)
确定中国广泛耐药肠杆菌科细菌的临床和环境影响、负担和成本 (DETER-XDRE-CHINA)
- 批准号:
MR/P007295/1 - 财政年份:2016
- 资助金额:
$ 197.82万 - 项目类别:
Research Grant
Assessing the situation of AMR of bacteria in Vietnam, determining genomic characteristics and associated factors of common AMR-bacteria in Vietnam
评估越南细菌的AMR状况,确定越南常见AMR细菌的基因组特征和相关因素
- 批准号:
MR/N028317/1 - 财政年份:2016
- 资助金额:
$ 197.82万 - 项目类别:
Research Grant
Combatting the threat of carbapenem resistance in Gram-negative bacterial pathogens
对抗革兰氏阴性细菌病原体的碳青霉烯类耐药性威胁
- 批准号:
G1100135/1 - 财政年份:2011
- 资助金额:
$ 197.82万 - 项目类别:
Research Grant
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