BEHAVIORAL PHYSIOLOGY OF BODY WEIGHT REGULATION

体重调节的行为生理学

• 批准号: 3241476
• 负责人: DIANNE FIGLEWICZ LATTEMANN
• 金额: $ 15.69万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3241476
• 关键词: animal age group; body weight; cerebral cortex; diacylglycerols; female; gender difference; growth /development; hippocampus; hormone regulation /control mechanism; hypothalamus; inositol; insulin; insulin receptor; ion exchange chromatography; laboratory rat; lipid metabolism; male; membrane lipids; neuroendocrine system; norepinephrine; nutrient intake activity; nutrition related tag; obesity; olfactory lobe; phospholipids; phosphorylation; protein kinase C; radioimmunoassay; receptor binding; thin layer chromatography; tritium; weight control

Studies have suggested that insulin may be a regulator of food intake and body weight by acting at the central nervous system (CNS). This renewal proposal addresses the hypothesis that the ability of insulin to act as a satiety signal may change during normal growth and development, and may be abnorrnal in obesity. Studies are proposed to examine whether insulin uptake into the CNS, or insulin action-in the CNS, is altered in rats as a function of age, gender, and genetic or diet-induced obesity. Insulin uptake by brain will be assessed in vivo by measurement of steady state levels of plasma and CSF insulin during vehicle or insulin infusions. Brain capillary insulin binding sites will be measured as an in vitro estimate of specific receptor-mediated transport capacity. Regulation of these receptors has been observed by this laboratory and others and may represent a potential mechanism for regulation of insulin uptake into the CNS. Insulin action will be assessed behaviorally by measuring body weight and food intake in response to intraventricular insulin infusions. Insulin action in vitro will be assessed by measurement of insulin effects on norepinephrine uptake and post-synaptic events in the hippocampus, a brain region in which I have demonstrated insulin stimulation of phospholipid metabolism which may be mediated locally by catecholamines, as well as in the hypothalamus and olfactory bulb, two brain regions which play a major role in the regulation of food intake and body weight, and compared with changes of peripheral insulin action. Together, these studies should determine whether the effectiveness of the candidate CNS adiposity signal, insulin, is regulated by changes in its uptake and/or action in the CNS.

研究表明胰岛素可能是食物摄入的调节器