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FISH MODEL FOR THE STUDY OF HEPATIC COPPER METABOLISM

FISH MODEL FOR THE STUDY OF HEPATIC COPPER METABOLISM
用于研究肝铜代谢的鱼模型
批准号:
3251350
负责人:
JOHN M FRAZIER
金额:
$9.89万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-09-01 至 1988-08-31

项目摘要

项目成果

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中文摘要
翻译
这项研究计划的总体目标是开发一种鱼类模型
英文摘要
The overall objective of this research program is to develop a fish model for the investigation of hepatic copper metabolism in order to advance our understanding of the molecular kinetics of copper in eukaryotic cells. Copper is a highly toxic metal and alterations in its normal metabolism result in severe cellular dysfunction, such as expressed in Wilson's disease. The white perch (Morone americana) accumulates exceptionally high copper concentrations in the liver (greater than 1000 Mug/g wet weight) under conditions of natural exposure. These levels are greatly in excess of hepatic copper concentrations observed in Wilson's disease patients. A closely related fish species, the striped bass (Morone saxatilis), exhibits hepatic copper levels similar to mammals and will serve as controls. The specific aim of this project is to determine the mechanisms which account for the abnormal accumulation of copper in white perch. Experimental studies using isolated hepatocytes and purified membrane preparations from these two fish species will investigate the role of membrane transport and intracellular protein binding in copper accumulation. A unique feature of this study is that the two fish species can be crossbred to produce hybrids which will allow us to investigate the genetic control of the accumulation factors. It is expected that this fish model will contribute new knowledge concerning the mechanisms which control copper kinetics in eukaryotic cells.
期刊论文(2)
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会议论文
Induction of metal binding proteins in striped bass, Morone saxatilis, following cadmium treatment.
镉处理后,条纹鲈鱼 (Morone saxatilis) 中金属结合蛋白的诱导。
DOI: 10.1016/0742-8413(88)90042-4
发表时间: 1988
期刊: Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
影响因子: --
作者: [Baksi,SM, Libbus,N, Frazier,JM]
通讯作者: Frazier,JM
CORE SUPPORT-CENTER FOR ALTERNATIVES TO ANIMAL TESTING
  • 批准号:
    2283015
  • 项目类别:
  • 资助金额:
    $8.72万
  • 财政年份:
    1989
  • 负责人:
    JOHN M FRAZIER
  • 依托单位:
CORE SUPPORT-CENTER FOR ALTERNATIVES TO ANIMAL TESTING
  • 批准号:
    3103556
  • 项目类别:
  • 资助金额:
    $7.99万
  • 财政年份:
    1989
  • 负责人:
    JOHN M FRAZIER
  • 依托单位:
CORE SUPPORT-CENTER FOR ALTERNATIVES TO ANIMAL TESTING
  • 批准号:
    3103555
  • 项目类别:
  • 资助金额:
    $7.68万
  • 财政年份:
    1989
  • 负责人:
    JOHN M FRAZIER
  • 依托单位:
CORE SUPPORT-CENTER FOR ALTERNATIVES TO ANIMAL TESTING
  • 批准号:
    3103553
  • 项目类别:
  • 资助金额:
    $7.32万
  • 财政年份:
    1989
  • 负责人:
    JOHN M FRAZIER
  • 依托单位:
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