Expanding the organometallic toolbox for constructing heterocycles

扩展构建杂环的有机金属工具箱

• 批准号: DP170104722
• 负责人: Prof Philip Andrews
• 金额: $ 37.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-02-28 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170104722
• 关键词: Expanding; organometallic; toolbox; constructing; heterocycles

This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules which are difficult to access. They will synthesise and characterise homo- and hetero-bimetallic complexes to develop cyclic molecules and scaffolds relevant in drug discovery. New molecules and reaction pathways will be relevant for biological and medicinal chemistry, and drug discovery programmes.

本项目旨在设计和合成立体定向环状分子。这对于化学家来说是一个问题，特别是当生物活性和药物相关性取决于复杂的立体化学和取代模式时。该团队将建立在他们发现的级联反应的基础上，用于合成高度立体特异性的吲哚衍生物。它们将靶向试剂和反应途径，以产生难以获得的杂环分子。他们将合成并合成同-和异-双链复合物，以开发与药物发现相关的环状分子和支架。新的分子和反应途径将与生物和药物化学以及药物发现方案有关。