Targeting Bio-Compatible Homo- and Hetero-bimetallic Cages and their Application in High Energy and Dual Energy Computed Tomography

针对生物相容性同质和异质双金属笼及其在高能和双能计算机断层扫描中的应用

• 批准号: DP140102093
• 负责人: Prof Philip Andrews
• 金额: $ 31.45万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-03-31 至 2017-11-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102093
• 关键词: Targeting; Bio; Compatible; Homo; Hetero

The project is focused on the synthesis, characterisation and stability of novel homo-metallic and hetero-metallic oxygen and sulfur based cage compounds which have the potential to be suitable for high energy and Dual Energy CT imaging (DECT), and also for optical imaging where rare-earth metals are involved. Pre-requisites for cage design are that they be stable and soluble in aqueous media, and be resistant to anionic ligand exchange at the cluster surface. The targeted metals are based on good attenuation at high (100 to 140 keV) and low X-ray (less than 30 keV) energies, and the possibility of high stability and low toxicity.

该项目的重点是新型同金属和异金属氧硫笼状化合物的合成、表征和稳定性，这些化合物可能适用于高能和双能CT成像(DECT)，也适用于涉及稀土金属的光学成像。笼子设计的先决条件是它们在水介质中稳定和溶解，并能抵抗团簇表面的阴离子配体交换。目标金属是基于在高(100至140keV)和低(小于30keV)X射线能量下的良好衰减，以及高稳定性和低毒性的可能性。