CONTROL OF CORNEAL HYDRATION AND TRANSPARENCY

控制角膜水合和透明度

基本信息

  • 批准号:
    3255413
  • 负责人:
  • 金额:
    $ 18.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1978
  • 资助国家:
    美国
  • 起止时间:
    1978-09-01 至 1993-08-31
  • 项目状态:
    已结题

项目摘要

The proposed research is designed to investigate two models of stress in the corneal endothelium and to establish on a quantitative basis the nature of the ion transport mechanisms in this cell layer are responsible for maintaining corneal hydration and transparency. A study of the effects of ultraviolet light on the corneal endothelium will seek to determine what is the primary site of injury that results in an increase in corneal hydration and marked changes in the appearance of the endothelium. It is postulated that an oxidative mechanism, provoked by the formation of free radicals following absorption of the high energy photons, causes damage to enzymes or membrane proteins and lipids. Structural changes that follow may result from alteration of cytoskeletal elements or from release of chemotactic factors that cause invasion of leukocytes that become attached to the endothelium. The hypothesis will be tested by assessing metabolic changes after UV exposure and the effects of changes in anti-oxidants and detoxifying or protective enzymes on the corneal response to UV. Defining the nature and origin of the structural changes will entail examination by a number of microscopy techniques, modification of the inflammatory response, and in vitro systems for testing chemotaxis and leukocyte recruitment. The diabetic study will seek in an animal model the basis for the failure of diabetic patients to withstand intraocular surgery without more severe corneal swelling than other patients. It is postulated that the endothelium is compromised by the disease in a manner which reduces the effectiveness or capacity of defensive or maintenance mechanisms, such that the pump or barrier functions are more vulnerable to subsequent insults. The effects of hyperglycaemia on the concentrations of sorbitol and inositol and upon inositol metabolism will be measured, as these may regulate protein kinase and Na+-K+ ATPase activities, and endothelial morphology and cell pattern will be followed to detect weakening of the barrier characteristics. Additional stresses and inhibitors of aldose reductase will be used to identify the key sites of damage. The study of ion transport in the endothelium will focus on the absolute values of fluxes and the extent of coupling in order to provide sound data for assessment of postulated mechanisms.
本研究旨在探讨两个模型

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MICHAEL V RILEY其他文献

MICHAEL V RILEY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MICHAEL V RILEY', 18)}}的其他基金

STRUCTURE/FUNCTION OF A TURMOR VIRUS CHAPERONE
肿瘤病毒伴侣的结构/功能
  • 批准号:
    7723126
  • 财政年份:
    2008
  • 资助金额:
    $ 18.47万
  • 项目类别:
STRUCTURE/FUNCTION OF A TURMOR VIRUS CHAPERONE
肿瘤病毒伴侣的结构/功能
  • 批准号:
    7601306
  • 财政年份:
    2007
  • 资助金额:
    $ 18.47万
  • 项目类别:
Structure/Function of a Tumor Virus Chaperone
肿瘤病毒伴侣的结构/功能
  • 批准号:
    6980136
  • 财政年份:
    2004
  • 资助金额:
    $ 18.47万
  • 项目类别:
STRUCTURE/FUNCTION OF A TURMOR VIRUS CHAPERONE
肿瘤病毒伴侣的结构/功能
  • 批准号:
    7181674
  • 财政年份:
    2004
  • 资助金额:
    $ 18.47万
  • 项目类别:
INSTRUMENTATION
仪器仪表
  • 批准号:
    3003363
  • 财政年份:
    1987
  • 资助金额:
    $ 18.47万
  • 项目类别:
BIOMEDICAL RESEARCH SUPPORT
生物医学研究支持
  • 批准号:
    3518533
  • 财政年份:
    1979
  • 资助金额:
    $ 18.47万
  • 项目类别:
BIOMEDICAL RESEARCH SUPPORT
生物医学研究支持
  • 批准号:
    3518536
  • 财政年份:
    1979
  • 资助金额:
    $ 18.47万
  • 项目类别:
BIOMEDICAL RESEARCH SUPPORT
生物医学研究支持
  • 批准号:
    3518535
  • 财政年份:
    1979
  • 资助金额:
    $ 18.47万
  • 项目类别:
BIOMEDICAL RESEARCH SUPPORT
生物医学研究支持
  • 批准号:
    3518534
  • 财政年份:
    1979
  • 资助金额:
    $ 18.47万
  • 项目类别:
CONTROL OF CORNEAL HYDRATION AND TRANSPARENCY
控制角膜水合和透明度
  • 批准号:
    3255421
  • 财政年份:
    1978
  • 资助金额:
    $ 18.47万
  • 项目类别:

相似海外基金

MOLECULAR CHARACTERIZATION OF THE SODIUM POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
  • 批准号:
    7461764
  • 财政年份:
    1974
  • 资助金额:
    $ 18.47万
  • 项目类别:
MOLECULAR CHARTERIZATION OF THE SODIUM-POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
  • 批准号:
    7352845
  • 财政年份:
    1973
  • 资助金额:
    $ 18.47万
  • 项目类别:
Molecular Characterization of the Sodium-Potassiumtransport Adenosinetriphosphatase
钠钾转运三磷酸腺苷酶的分子表征
  • 批准号:
    7301506
  • 财政年份:
    1973
  • 资助金额:
    $ 18.47万
  • 项目类别:
    Continuing Grant
MOLECULAR CHARACTERIZATION OF THE SODIUM-POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
  • 批准号:
    7243716
  • 财政年份:
    1972
  • 资助金额:
    $ 18.47万
  • 项目类别:
MOLECULAR CHARACTERIZATION OF THE SODIUM-POTASSIUM TRANSPORT ADENOSINETRIPHOSPHATASE
钠钾转运腺苷三磷酸酶的分子表征
  • 批准号:
    7138222
  • 财政年份:
    1971
  • 资助金额:
    $ 18.47万
  • 项目类别:
Molecular Characterization of the Sodium-Potassium Transport Adenosinetriphosphatase
钠钾转运三磷酸腺苷酶的分子表征
  • 批准号:
    6928993
  • 财政年份:
    1969
  • 资助金额:
    $ 18.47万
  • 项目类别:
Adenosinetriphosphatase Genesis in Bone Marrow Cells
骨髓细胞中腺苷三磷酸酶的发生
  • 批准号:
    64B2295
  • 财政年份:
    1964
  • 资助金额:
    $ 18.47万
  • 项目类别:
Adenosinetriphosphatase and sugar Transport Mechanism
三磷酸腺苷酶和糖转运机制
  • 批准号:
    6216854
  • 财政年份:
    1962
  • 资助金额:
    $ 18.47万
  • 项目类别:
Bone Marrow Cells and Relation to Adenosinetriphosphatase Activity
骨髓细胞及其与三磷酸腺苷酶活性的关系
  • 批准号:
    6216803
  • 财政年份:
    1962
  • 资助金额:
    $ 18.47万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了