ELECTROMAGNETIC FIELDS AND ADULT MALIGNANT GLIOMA

恶性胶质瘤是我国最常见的原发恶性脑肿瘤 成年人，会使人虚弱并迅速致死。人们对此知之甚少 其原因；儿童的住宿研究和#年的职业研究 成年人认为极低频率的电磁场 (EMF)暴露可能是一个因素。关于成人脑癌的研究还没有 还进行了全面的电磁场暴露评估，包括 住宅、职业和其他曝光物。我们目前正在 进行一项由NCI资助的、以人群为基础的大型病例对照研究 旧金山湾区的恶性胶质瘤。案例(n等于 大约550人是新近被诊断出患有组织学疾病的成年人 91年8月1日至1994年7月30日确诊为恶性胶质瘤。年龄、性别和 比赛匹配控制(n等于约550)通过以下方式获得 随机数字拨号。结构化面试询问与以下内容相关的问题 电磁场暴露，包括详细的职业史，以实现 职业性电磁场暴露持续时间的分类.历史和 使用特定用具(或其他电子设备，如 作为业余无线电)；以及受试者在15年前居住的所有地址 学习条目。在这项拟议的研究中，我们将添加住宅电动势 暴露评估包括：(1)使用 使用EMDEX仪表进行测量的预测试协议，(2) 电力线、变压器和变电所的特性 住宅，以及(3)住宅的Werthemer-Leeper类型线码。 当前住宅(n约等于1100)和 每一科目在入学前15年内的加利福尼亚州 (n约等于1870)将被考虑。10%的样本 住宅将被盲目地重新评估。流行病学和工业 卫生数据将用于开发基于以下条件的电磁场暴露矩阵 住宅外部布线等特点、职业、以及 电器的使用。统计分析将检验假设 与对照组相比，患者更有可能生活在与 高电流VS低电流配置布线；案例生活在 平均电磁场强度较高的住宅(或其他指标，如 如峰值、方差或变化率)比对照组；并且病例有 比基于每个EMF暴露矩阵的对照组更大的EMF暴露 在复合矩阵上。这将是对成人大脑的第一次研究 癌症将结合住宅电磁场暴露信息， 职业和其他来源，以及第一个提供 住宅电磁场暴露信息以及 电码。

Malignant glioma, the most common primary malignant brain tumor in adults, is debilitating and rapidly fatal. Very little is known about its causes; residential studies in children and occupational studies in adults have suggested that extremely low-frequency electromagnetic field (EMF) exposures may be a factor. Studies of adult brain cancer have not yet undertaken an overall EMF exposure assessment incorporating residential, occupational, and other exposures. We are currently conducting a large, NCI-funded, population-based case-control study of malignant glioma in the San Francisco Bay Area. Cases (n equals approximately 550) are adults newly diagnosed with histologically confirmed malignant glioma from 8/1/91-7/30/94. Age-, sex-, and race-matched controls (n equals approximately 550) are obtained through random-digit dialing. Structured interviews ask questions pertinent to EMF exposure including detailed occupational histories to enable classification of occupational EMF exposures with duration; history and frequency of use of specific appliances (or other electric devices such as ham radios); and all addresses where subjects lived 15 years prior to study entry. In this proposed study, we will add a residential EMF exposure assessment consisting of (1) home spot measures using a pretested protocol for measurement with EMDEX meters, (2) characterization of power lines, transformers, and substations near the residence, and (3) Wertheimer-Leeper type wire-codes for the residence. Current residences (n equals approximately 1100) and all residences in the state of California of each subject for 15 years prior to study entry (n equals approximately 1870) will be considered. A 10% sample of all residences will be reassessed, blindly. Epidemiologic and industrial hygiene data will be used to develop EMF exposure matrices based on external residential wiring and other characteristics, occupation, and electric appliance use. Statistical analyses will test hypotheses that cases were more likely than controls to have lived in a residence with high current vs low current configuration wiring; that cases lived in residences with higher average EMF field strengths (or other metrics such as peaks, variance, or rate of change) than controls; and that cases had greater EMF exposure than controls based on each EMF exposure matrix and on a composite matrix. This will be the first study of adult brain cancer to combine information on EMF exposures from residential, occupational, and other sources as well as the first to provide residential EMF exposure information in addition to that contained in wire-codes.