ELECTROMAGNETIC FIELDS AND ADULT MALIGNANT GLIOMA

电磁场和成人恶性神经胶质瘤

• 批准号: 2155159
• 负责人: MARGARET R. WRENSCH
• 金额: $ 20.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-12-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2155159
• 关键词: adult human (21+); cancer risk; electric field; environment related neoplasm /cancer; gender difference; geographic site; glioma; housing; human subject; interview; magnetic field; neoplasm /cancer epidemiology; occupational hazard; racial /ethnic difference; radiation related neoplasm /cancer; socioenvironment; statistics /biometry; work site

Malignant glioma, the most common primary malignant brain tumor in adults, is debilitating and rapidly fatal. Very little is known about its causes; residential studies in children and occupational studies in adults have suggested that extremely low-frequency electromagnetic field (EMF) exposures may be a factor. Studies of adult brain cancer have not yet undertaken an overall EMF exposure assessment incorporating residential, occupational, and other exposures. We are currently conducting a large, NCI-funded, population-based case-control study of malignant glioma in the San Francisco Bay Area. Cases (n equals approximately 550) are adults newly diagnosed with histologically confirmed malignant glioma from 8/1/91-7/30/94. Age-, sex-, and race-matched controls (n equals approximately 550) are obtained through random-digit dialing. Structured interviews ask questions pertinent to EMF exposure including detailed occupational histories to enable classification of occupational EMF exposures with duration; history and frequency of use of specific appliances (or other electric devices such as ham radios); and all addresses where subjects lived 15 years prior to study entry. In this proposed study, we will add a residential EMF exposure assessment consisting of (1) home spot measures using a pretested protocol for measurement with EMDEX meters, (2) characterization of power lines, transformers, and substations near the residence, and (3) Wertheimer-Leeper type wire-codes for the residence. Current residences (n equals approximately 1100) and all residences in the state of California of each subject for 15 years prior to study entry (n equals approximately 1870) will be considered. A 10% sample of all residences will be reassessed, blindly. Epidemiologic and industrial hygiene data will be used to develop EMF exposure matrices based on external residential wiring and other characteristics, occupation, and electric appliance use. Statistical analyses will test hypotheses that cases were more likely than controls to have lived in a residence with high current vs low current configuration wiring; that cases lived in residences with higher average EMF field strengths (or other metrics such as peaks, variance, or rate of change) than controls; and that cases had greater EMF exposure than controls based on each EMF exposure matrix and on a composite matrix. This will be the first study of adult brain cancer to combine information on EMF exposures from residential, occupational, and other sources as well as the first to provide residential EMF exposure information in addition to that contained in wire-codes.

恶性胶质瘤是脑内最常见的原发性恶性肿瘤， 成年人，是衰弱和迅速致命的。 很少有人知道 其原因;儿童的住宿研究和职业研究， 成年人认为极低频电磁场 (EMF)暴露可能是一个因素。 对成人脑癌的研究还没有 但进行了一项总体电磁场暴露评估， 住宅、职业和其他暴露。 我们目前正在 进行了一项大型的，NCI资助的，以人群为基础的病例对照研究， 弗朗西斯科湾区的恶性神经胶质瘤 案例（n等于 大约550人）是新诊断的组织学上 1991年8月1日至1994年7月30日确诊恶性胶质瘤。 年龄、性别和 通过以下方法获得种族匹配对照（n约等于550）： 随机数字拨号 结构化面试会询问与以下内容相关的问题： EMF暴露，包括详细的职业史， 职业EMF暴露的分类与持续时间;历史和 使用特定电器（或其他电气设备， 业余无线电）;以及受试者15年前居住的所有地址 研究入口。 在这项建议的研究中，我们会加入一个住宅电磁场， 暴露评估包括（1）使用 使用EMDEX血糖仪进行测量的预测试协议，（2） 电力线，变压器和变电站附近的表征 住宅，以及（3）住宅的Wertheimer-Leeper型有线代码。 目前居住地（n约等于1100）和所有居住地 研究入组前15年，每例受试者的加州 （n = 1870）。 10%的样本 住宅将被盲目地重新评估。 流行病学和工业 卫生数据将用于制定电磁场暴露矩阵， 住宅外部布线等特点，职业， 电器使用。 统计分析将检验假设， 病例比对照组更有可能居住在 高电流与低电流配置布线;案例生活在 具有较高平均EMF场强的住宅（或其他指标， 峰值、方差或变化率）;并且病例 基于每个EMF暴露矩阵，EMF暴露大于对照组， 在一个复合矩阵上。 这将是第一次对成年人大脑的研究 联合收割机结合住宅电磁场暴露的信息， 职业和其他来源以及第一个提供 住宅电磁场暴露信息，除了包含在 wire-codes.