INDOOR RADON LEVELS, CIGARETTE SMOKING AND CANCER

室内氡气水平、吸烟与癌症

• 批准号: 3253320
• 负责人: William J Nicholson
• 金额: $ 31.84万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-15 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3253320
• 关键词: cancer risk; chemical related neoplasm /cancer; diet; environment related neoplasm /cancer; housing; human subject; lung neoplasms; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; occupational hazard; radiation related neoplasm /cancer; radon; tobacco abuse

DESCRIPTION (Adapted from the investigator's abstract):The objective of this study is to investigate the relationship between home exposure to radon and lung cancer. This will be done through an analysis of 689 histologically confirmed cases of lung cancer and 744 age, sex and smoking matched controls. A similar case-control analysis will be conducted for 46 lung cancer cases among non-smokers, matched with 92 age and sex matched controls.The study will be conducted in five counties of Northwest New Jersey, a geographic area with one of the largest and most intense radon releasing formations in the United States. Year-long radon measurements will be made and house construction features evaluated in all the homes lived in by study subjects over the period 5 to 30 years prior to case or control subject identification. The relative risk of radon exposure will be calculated using both stratified techniques and regression analyses.Information on other cancer risk factors in the diet, environment and work of each study subject will be obtained and considered in the analyses.

说明(改编自调查员摘要)：目标 本研究旨在探讨家居暴露与健康的关系。 氡和肺癌。这将通过对689个 经组织学证实的肺癌病例和744例年龄、性别和 吸烟与对照组相匹配。类似的病例对照分析将是 在46例非吸烟者中进行了肺癌调查，与92例进行了匹配 年龄和性别匹配的对照组。这项研究将在五年内进行 新泽西州西北部的几个县，这是一个地理区域 美国最大和最强烈的氡释放层 各州。将进行为期一年的氡测量，并建造房屋 研究对象在过去一年中对所有家庭的特征进行了评估 在病例或对照对象确定前5至30年内。 氡暴露的相对风险将使用这两种方法计算 分层技术和回归分析。其他信息 每项研究的饮食、环境和工作中的癌症危险因素 主题将被获得并在分析中考虑。