RADON LEVELS, CIGARETTE SMOKING EXPOSURE, AND CANCER

氡气水平、吸烟暴露与癌症

• 批准号: 3253318
• 负责人: William J Nicholson
• 金额: $ 46.8万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-15 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3253318
• 关键词: cancer information system; cancer risk; chemical related neoplasm /cancer; environment related neoplasm /cancer; histopathology; interview; lung neoplasms; nicotine; nutrition aspect of cancer; occupational hazard; radon; tobacco abuse

The objective of this study is to investigate the relationship between home exposure to radon and lung cancer. This will be done through an analysis of 425 hist ologically confirmed cases of lung cancer and 425 age, sex and smoking matched controls. A similar case-control analysis will be conducted of 85 lung cancer cases among non-smokers, matched with 170 age and sex matched controls. The study will be conducted in five counties of Northwest New Jersey, an area with one of the geographically largest and intense radon releasing formations in the United States. Year-long radon measurements will be made and house construction features evaluated in all the homes lived in by study subjects over the period 5 to 30 years prior to case or control subject identification. The relative risk of radon exposure will be calculated using both stratified techniques and regression analyses. Additionally, a more sensitive analysts technique will be developed that takes advantage of information on individual smoking risks from large, general population studies. Information on other cancer risk factors in the diet, environment and work of each study subject will be obtained and considered in the analyses.

本研究的目的是调查之间的关系 家庭暴露于氡气和肺癌。这将通过一个 对 425 例经组织学确诊的肺癌病例和 425 例肺癌病例进行分析 年龄、性别和吸烟情况与对照相匹配。类似的病例对照分析 将对 85 名非吸烟者肺癌病例进行研究，并与 170 名年龄和性别匹配的对照。该研究将分五期进行 新泽西州西北部的县，该地区是地理上最 美国最大、最强烈的氡气释放地层。 将进行为期一年的氡气测量和房屋建筑特征 对研究对象在 5 年间居住的所有房屋进行评估 至病例或对照对象识别前 30 年。亲戚 氡暴露风险将使用分层计算 技术和回归分析。此外，还有一个更灵敏的 将开发利用信息的分析技术 来自大型普通人群研究的个人吸烟风险。 有关饮食、环境和其他癌症危险因素的信息 每个研究主题的工作将被获得并在 分析。