Effects of AGE/RAGE on Monocytes in Arteriogenesis

AGE/RAGE 对单核细胞动脉生成的影响

• 批准号: 6836913
• 负责人: William J Nicholson
• 金额: $ 4.66万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-29 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836913
• 关键词: angiogenesis; biological signal transduction; blood vessel occlusion; diabetes mellitus; diabetic angiopathy; flow cytometry; glycation; laboratory mouse; monocyte; polymerase chain reaction; postdoctoral investigator; receptor

DESCRIPTION (provided by applicant): By the year 2010 it is projected that the total number of people worldwide with diabetes will reach 221 million, with as many as 80% of these patients succumb to complications closely associated with vascular disease. The capacity to form collateral blood vessels is vital to compensate for tissue ischemia resulting from vascular occlusive disease, and this ability is significantly decreased in the diabetic patient. The formation of advanced glycation endproducts (AGEs) occurs in the normal process of aging, but is enhanced in the chronic hyperglycemic state of diabetes. AGEs have been implicated in the development of diabetic vascular complications. Monocytes play an important role in the arteriogenic process and during collateral growth and are known to be affected by AGEs. The specific aims of this project are to examine the effects of monocyte expression of the receptor for AGE in diabetic mice on arteriogenesis via hind-limb ischemia appraised by microcomputed tomography, and to examine the functional consequences of AGE/RAGE stimulation on the inherent motility of monocytes derived from the above model.

描述（由申请人提供）：预计到2010年，全球糖尿病患者总数将达到2.21亿，其中多达80%的患者死于与血管疾病密切相关的并发症。形成侧支血管的能力对于补偿由血管闭塞性疾病引起的组织缺血是至关重要的，并且这种能力在糖尿病患者中显著降低。 晚期糖基化终产物（AGEs）的形成发生在正常的衰老过程中，但在糖尿病的慢性高血糖状态下会增强。AGEs与糖尿病血管并发症的发生有关。 单核细胞在动脉形成过程和侧枝生长过程中起着重要作用，并且已知受到AGEs的影响。本项目的具体目的是研究糖尿病小鼠中AGE受体的单核细胞表达对通过微计算机断层扫描评估的后肢缺血的动脉生成的影响，并研究AGE/ESTA刺激对来自上述模型的单核细胞的固有运动性的功能后果。