RADON LEVELS, CIGARETTE SMOKING EXPOSURE, AND CANCER

氡气水平、吸烟暴露与癌症

• 批准号: 3253323
• 负责人: William J Nicholson
• 金额: $ 54.8万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-15 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3253323
• 关键词: cancer information system; cancer risk; chemical related neoplasm /cancer; environment related neoplasm /cancer; histopathology; interview; lung neoplasms; nicotine; nutrition aspect of cancer; occupational hazard; radon; tobacco abuse

The objective of this study is to investigate the relationship between home exposure to radon and lung cancer. This will be done through an analysis of 425 hist ologically confirmed cases of lung cancer and 425 age, sex and smoking matched controls. A similar case-control analysis will be conducted of 85 lung cancer cases among non-smokers, matched with 170 age and sex matched controls. The study will be conducted in five counties of Northwest New Jersey, an area with one of the geographically largest and intense radon releasing formations in the United States. Year-long radon measurements will be made and house construction features evaluated in all the homes lived in by study subjects over the period 5 to 30 years prior to case or control subject identification. The relative risk of radon exposure will be calculated using both stratified techniques and regression analyses. Additionally, a more sensitive analysts technique will be developed that takes advantage of information on individual smoking risks from large, general population studies. Information on other cancer risk factors in the diet, environment and work of each study subject will be obtained and considered in the analyses.

本研究的目的是探讨 氡和肺癌的关系。这将通过一个 肺癌425例临床病理分析 年龄、性别和吸烟匹配的对照组。相似病例对照分析 将对85例非吸烟者肺癌病例进行研究， 170名年龄和性别匹配的对照。该研究将在五个 美国新泽西西北部各县，地理上是 美国最大最强的氡释放层 将进行长达一年的氡气测量， 在研究对象居住的所有家庭中进行评估， 至病例或对照受试者识别前30年。的相对 氡暴露的风险将使用两个分层 技术和回归分析。此外，更敏感的 将开发利用信息的分析技术 大型一般人群研究中的个人吸烟风险。 关于饮食、环境和环境中其他癌症风险因素的信息 每个研究对象的工作将在 分析。